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'''THIRD N-TERMINAL DOMAIN OF GP130, NMR, MINIMIZED AVERAGE STRUCTURE''' | '''THIRD N-TERMINAL DOMAIN OF GP130, NMR, MINIMIZED AVERAGE STRUCTURE''' | ||
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[[Category: Scheek, R M.]] | [[Category: Scheek, R M.]] | ||
[[Category: Wollmer, A.]] | [[Category: Wollmer, A.]] | ||
[[Category: | [[Category: Glycoprotein]] | ||
[[Category: | [[Category: Receptor]] | ||
[[Category: | [[Category: Signal transducer of il-6 type cytokine]] | ||
[[Category: | [[Category: Third n-terminal domain]] | ||
[[Category: | [[Category: Transmembrane]] | ||
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Revision as of 08:35, 2 May 2008
THIRD N-TERMINAL DOMAIN OF GP130, NMR, MINIMIZED AVERAGE STRUCTURE
Overview
The transmembrane glycoprotein gp130 is the common signal transducing receptor subunit of the interleukin-6-type cytokines. It is a member of the cytokine-receptor superfamily predicted to consist of six domains in its extracellular part. The second and third domain constitute the cytokine-binding module defined by a set of four conserved cysteines and a WSXWS motif, respectively. The three-dimensional structure of the carboxy-terminal domain of this region was determined by multidimensional NMR. The domain consists of seven beta-strands constituting a fibronectin type III-like topology. The structure reveals that the WSDWS motif of gp130 is part of an extended tryptophan/arginine zipper which modulates the conformation of the CD loop.
About this Structure
1BJ8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The signal transducer gp130: solution structure of the carboxy-terminal domain of the cytokine receptor homology region., Kernebeck T, Pflanz S, Muller-Newen G, Kurapkat G, Scheek RM, Dijkstra K, Heinrich PC, Wollmer A, Grzesiek S, Grotzinger J, Protein Sci. 1999 Jan;8(1):5-12. PMID:10210178 Page seeded by OCA on Fri May 2 11:35:08 2008
