1bmp: Difference between revisions
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'''BONE MORPHOGENETIC PROTEIN-7''' | '''BONE MORPHOGENETIC PROTEIN-7''' | ||
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[[Category: Griffith, D L.]] | [[Category: Griffith, D L.]] | ||
[[Category: Scott, D L.]] | [[Category: Scott, D L.]] | ||
[[Category: | [[Category: Bone]] | ||
[[Category: | [[Category: Cartilage]] | ||
[[Category: | [[Category: Cytokine]] | ||
[[Category: | [[Category: Glycoprotein]] | ||
[[Category: | [[Category: Morphogen]] | ||
[[Category: | [[Category: Transforming growth factor]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:42:24 2008'' | |||
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Revision as of 08:42, 2 May 2008
BONE MORPHOGENETIC PROTEIN-7
Overview
We report the three-dimensional structure of osteogenic protein 1 (OP-1, also known as bone morphogenetic protein 7) to 2.8-A resolution. OP-1 is a member of the transforming growth factor beta (TGF-beta) superfamily of proteins and is able to induce new bone formation in vivo. Members of this superfamily share sequence similarity in their C-terminal regions and are implicated in embryonic development and adult tissue repair. Our crystal structure makes possible the structural comparison between two members of the TGF-beta superfamily. We find that although there is limited sequence identity between OP-1 and TGF-beta 2, they share a common polypeptide fold. These results establish a basis for proposing the OP-1/TGF-beta 2 fold as the primary structural motif for the TGF-beta superfamily as a whole. Detailed comparison of the OP-1 and TGF-beta 2 structures has revealed striking differences that provide insights into how these growth factors interact with their receptors.
About this Structure
1BMP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily., Griffith DL, Keck PC, Sampath TK, Rueger DC, Carlson WD, Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):878-83. PMID:8570652 Page seeded by OCA on Fri May 2 11:42:24 2008
