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'''SL3 HAIRPIN FROM THE PACKAGING SIGNAL OF HIV-1, NMR, 11 STRUCTURES''' | '''SL3 HAIRPIN FROM THE PACKAGING SIGNAL OF HIV-1, NMR, 11 STRUCTURES''' | ||
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==About this Structure== | ==About this Structure== | ||
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BN0 OCA]. | |||
==Reference== | ==Reference== | ||
Three-dimensional folding of an RNA hairpin required for packaging HIV-1., Pappalardo L, Kerwood DJ, Pelczer I, Borer PN, J Mol Biol. 1998 Oct 2;282(4):801-18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9743628 9743628] | Three-dimensional folding of an RNA hairpin required for packaging HIV-1., Pappalardo L, Kerwood DJ, Pelczer I, Borer PN, J Mol Biol. 1998 Oct 2;282(4):801-18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9743628 9743628] | ||
[[Category: Borer, P N.]] | [[Category: Borer, P N.]] | ||
[[Category: Kerwood, D J.]] | [[Category: Kerwood, D J.]] | ||
[[Category: Pappalardo, L.]] | [[Category: Pappalardo, L.]] | ||
[[Category: Pelczer, I.]] | [[Category: Pelczer, I.]] | ||
[[Category: | [[Category: Hiv-1]] | ||
[[Category: | [[Category: Nmr]] | ||
[[Category: | [[Category: Packaging]] | ||
[[Category: | [[Category: Ribonucleic acid]] | ||
[[Category: | [[Category: Rna]] | ||
[[Category: | [[Category: Tetraloop]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:43:04 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 08:43, 2 May 2008
SL3 HAIRPIN FROM THE PACKAGING SIGNAL OF HIV-1, NMR, 11 STRUCTURES
Overview
An NMR-based structure is presented for a 20 mer hairpin model of the SL3 stem-loop from the HIV-1 packaging signal. The stem has an A-family structure. However, the GGAG tetraloop appears to be flexible with the second (G10) and fourth (G12) bases extruded from the normal stacking arrangement. The A-base (A11) occupies a cavity large enough for it to jump rapidly between stacking upon G9 (in the loop) and G13 (from the base-pair adjacent to the loop). The H-bonding loci of G10, A11, and G12 are unoccupied in the free RNA structure. The loop should be easily adaptable to binding by the HIV-1 nucleocapsid protein or loop receptors.
About this Structure
Full crystallographic information is available from OCA.
Reference
Three-dimensional folding of an RNA hairpin required for packaging HIV-1., Pappalardo L, Kerwood DJ, Pelczer I, Borer PN, J Mol Biol. 1998 Oct 2;282(4):801-18. PMID:9743628 Page seeded by OCA on Fri May 2 11:43:04 2008
