EPSP synthase: Difference between revisions
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<StructureSection load='1g6s' size='350' side='right' caption='Structure of EPSP synthase (PDB entry [[ | <StructureSection load='1g6s' size='350' side='right' caption='Structure of E. coli EPSP synthase complex with shikimate-3-phosphate, the herbicide glyphosate and formic acid (PDB entry [[1g6s]])' scene=''> | ||
== Function == | == Function == | ||
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== Relevance == | == Relevance == | ||
EPSP synthase is a target for drugs and herbicides. | EPSP synthase is a target for drugs and herbicides like '''Roundup'''. | ||
== Structural insights == | == Structural insights == | ||
The enzyme has <scene name='57/570585/Two_domains/1'>two domains</scene>, with the active site found in the interdomain cleft. There is a substantial structural change upon substrate binding, resulting in a <scene name='57/570585/Closed_formation/1'>closed formation</scene>. '''Glyphosate''' (also known as '''Roundup''') occupies the binding site of the second substrate, phosphoenol pyruvate. | The enzyme has <scene name='57/570585/Two_domains/1'>two domains</scene>, with the active site found in the interdomain cleft. There is a substantial structural change upon substrate binding, resulting in a <scene name='57/570585/Closed_formation/1'>closed formation</scene>. '''Glyphosate''' (also known as '''Roundup''') occupies the binding site of the second substrate, phosphoenol pyruvate <ref>PMID:11171958</ref>. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 21:51, 19 January 2016
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3D structures of EPSP synthase
Updated on 19-January-2016
References
Proteopedia Page Contributors and Editors (what is this?)
Ann Taylor, Michal Harel, Alexander Berchansky, Joel L. Sussman
