5fql: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5fql is ~~ON HOLD until Paper Publication~~

==Insights into Hunter syndrome from the structure of iduronate-2- sulfatase==

~~Authors~~: ~~Demydchuk~~, M., ~~Hill~~, C.H., ~~Zhou~~, A., ~~Bunkoczi~~, G., ~~Stein, P~~.E., ~~Marchesan, D~~.~~, Deane, J~~.E., ~~Read~~, R.J.

== Structural highlights ==

<table><tr><td colspan='2'>[[5fql]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FQL OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FQL FirstGlance].

~~Description~~: ~~Insights into Hunter syndrome from~~ the ~~structure~~ of ~~iduronate~~-2-sulfatase

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=ALS:(3S)-3-(SULFOOXY)-L-SERINE'>ALS</scene></td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Iduronate-2-sulfatase Iduronate-2-sulfatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.6.13 3.1.6.13] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fql OCA], [http://pdbe.org/5fql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fql RCSB], [http://www.ebi.ac.uk/pdbsum/5fql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fql ProSAT]</td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/IDS_HUMAN IDS_HUMAN]] Mucopolysaccharidosis type 2, attenuated form;Mucopolysaccharidosis type 2, severe form. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[[http://www.uniprot.org/uniprot/IDS_HUMAN IDS_HUMAN]] Required for the lysosomal degradation of heparan sulfate and dermatan sulfate.

__TOC__

</StructureSection>

[[Category: Iduronate-2-sulfatase]]

[[Category: Bunkoczi, G]]

[[Category: Deane, J E]]

[[Category: Demydchuk, M]]

[[Category: Hill, C H]]

[[Category: Marchesan, D]]

[[Category: Read, R J]]

[[Category: Stein, P E]]

[[Category: Zhou, A]]

[[Category: ~~Marchesan, D~~]]

[[Category: Hunter syndrome]]

[[Category: ~~Bunkoczi, G]]~~

[[Category: Hydrolase]]

~~[[Category: Deane, J.E]]~~

~~[[Category: Stein, P.E]]~~

~~[[Category: Read, R.J]]~~

~~[[Category: Hill, C.H~~]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5fql is ON HOLD  until Paper Publication
+==Insights into Hunter syndrome from the structure of iduronate-2- sulfatase==
+<StructureSection load='5fql' size='340' side='right' caption='[[5fql]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-Authors: Demydchuk, M., Hill, C.H., Zhou, A., Bunkoczi, G., Stein, P.E., Marchesan, D., Deane, J.E., Read, R.J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5fql]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FQL FirstGlance]. <br>
-Description: Insights into Hunter syndrome from the structure of iduronate-2-sulfatase
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALS:(3S)-3-(SULFOOXY)-L-SERINE'>ALS</scene></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Iduronate-2-sulfatase Iduronate-2-sulfatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.6.13 3.1.6.13] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fql OCA], [http://pdbe.org/5fql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fql RCSB], [http://www.ebi.ac.uk/pdbsum/5fql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fql ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/IDS_HUMAN IDS_HUMAN]] Mucopolysaccharidosis type 2, attenuated form;Mucopolysaccharidosis type 2, severe form. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/IDS_HUMAN IDS_HUMAN]] Required for the lysosomal degradation of heparan sulfate and dermatan sulfate.
+__TOC__
+</StructureSection>
+[[Category: Iduronate-2-sulfatase]]
+[[Category: Bunkoczi, G]]
+[[Category: Deane, J E]]
 [[Category: Demydchuk, M]]
+[[Category: Hill, C H]]
+[[Category: Marchesan, D]]
+[[Category: Read, R J]]
+[[Category: Stein, P E]]
 [[Category: Zhou, A]]
-[[Category: Marchesan, D]]
+[[Category: Hunter syndrome]]
-[[Category: Bunkoczi, G]]
+[[Category: Hydrolase]]
-[[Category: Deane, J.E]]
-[[Category: Stein, P.E]]
-[[Category: Read, R.J]]
-[[Category: Hill, C.H]]