5fsn: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5fsn ~~is ON HOLD~~

==MTH1 substrate recognition: Complex with a aminomethylpyrimidinyl oxypropanol.==

~~Authors~~: ~~Nissink, J~~.W.M.~~, Bista, M~~.~~, Breed, J~~.~~, Carter, N~~.~~, Embrey, K~~., ~~Read~~, J., ~~Phillips~~, C., ~~Winter~~, ~~J.J.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5fsn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FSN OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FSN FirstGlance].

~~Description~~: ~~MTH1 substrate recognition~~: ~~Complex with a aminomethylpyrimidinyl oxypropanol~~.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=6Q3:3-(2-AMINO-6-METHYL-PYRIMIDIN-4-YL)OXYPROPAN-1-OL'>6Q3</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

[[~~Category~~: ~~Winter, J~~.J]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fsn OCA], [http://pdbe.org/5fsn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fsn RCSB], [http://www.ebi.ac.uk/pdbsum/5fsn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fsn ProSAT]</td></tr>

[[~~Category~~: ~~Nissink, J~~.W.M]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Bista, M]]

[[Category: Breed, J]]

[[Category: Carter, N]]

[[Category: Embrey, K]]

[[Category: ~~Carter~~, N]]

[[Category: Nissink, J W.M]]

[[Category: Phillips, C]]

~~[[Category: Breed, J]]~~

[[Category: Read, J]]

[[Category: Winter, J J]]

[[Category: Hydrolase]]

[[Category: Nudt1]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5fsn is ON HOLD
+==MTH1 substrate recognition: Complex with a aminomethylpyrimidinyl oxypropanol.==
+<StructureSection load='5fsn' size='340' side='right' caption='[[5fsn]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
-Authors: Nissink, J.W.M., Bista, M., Breed, J., Carter, N., Embrey, K., Read, J., Phillips, C., Winter, J.J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5fsn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FSN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FSN FirstGlance]. <br>
-Description: MTH1 substrate recognition: Complex with a aminomethylpyrimidinyl oxypropanol.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6Q3:3-(2-AMINO-6-METHYL-PYRIMIDIN-4-YL)OXYPROPAN-1-OL'>6Q3</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fsi|5fsi]], [[5fsk|5fsk]], [[5fsl|5fsl]], [[5fsm|5fsm]], [[5fso|5fso]]</td></tr>
-[[Category: Winter, J.J]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fsn OCA], [http://pdbe.org/5fsn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fsn RCSB], [http://www.ebi.ac.uk/pdbsum/5fsn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fsn ProSAT]</span></td></tr>
-[[Category: Nissink, J.W.M]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Bista, M]]
+[[Category: Breed, J]]
+[[Category: Carter, N]]
 [[Category: Embrey, K]]
-[[Category: Carter, N]]
+[[Category: Nissink, J W.M]]
 [[Category: Phillips, C]]
-[[Category: Breed, J]]
 [[Category: Read, J]]
+[[Category: Winter, J J]]
+[[Category: Hydrolase]]
+[[Category: Nudt1]]