5hh4: Difference between revisions
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==Crystal structure of metallo-beta-lactamase IMP-1 in complex with a phosphonate-based inhibitor== | |||
<StructureSection load='5hh4' size='340' side='right' caption='[[5hh4]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5hh4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HH4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HH4 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=60M:6-(PHOSPHONOMETHYL)PYRIDINE-2-CARBOXYLIC+ACID'>60M</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hh4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hh4 OCA], [http://pdbe.org/5hh4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hh4 RCSB], [http://www.ebi.ac.uk/pdbsum/5hh4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hh4 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/BLAB_SERMA BLAB_SERMA]] Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Beta-lactamase]] | |||
[[Category: Hinchliffe, P]] | |||
[[Category: Spencer, J]] | [[Category: Spencer, J]] | ||
[[Category: | [[Category: Antibiotic resistance]] | ||
[[Category: Carbapenamase]] | |||
[[Category: Hydrolase]] | |||
[[Category: Inhibitor]] | |||
[[Category: Phosphonate]] | |||
[[Category: Pyridine]] | |||
Revision as of 00:40, 19 January 2017
Crystal structure of metallo-beta-lactamase IMP-1 in complex with a phosphonate-based inhibitor
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