1bqh: Difference between revisions
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{{STRUCTURE_1bqh| PDB=1bqh | SCENE= }} | |||
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'''MURINE CD8AA ECTODOMAIN FRAGMENT IN COMPLEX WITH H-2KB/VSV8''' | '''MURINE CD8AA ECTODOMAIN FRAGMENT IN COMPLEX WITH H-2KB/VSV8''' | ||
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[[Category: Reinherz, E L.]] | [[Category: Reinherz, E L.]] | ||
[[Category: Wang, J H.]] | [[Category: Wang, J H.]] | ||
[[Category: | [[Category: Antigen]] | ||
[[Category: | [[Category: Complex]] | ||
[[Category: | [[Category: Coreceptor]] | ||
[[Category: | [[Category: Glycoprotein]] | ||
[[Category: | [[Category: Immunology]] | ||
[[Category: | [[Category: Signal]] | ||
[[Category: | [[Category: T-cell]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:49:54 2008'' | |||
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Revision as of 08:49, 2 May 2008
MURINE CD8AA ECTODOMAIN FRAGMENT IN COMPLEX WITH H-2KB/VSV8
Overview
The crystal structure of the two immunoglobulin variable-like domains of the murine CD8alphaalpha homodimer complexed to the class I MHC H-2Kb molecule at 2.8 A resolution shows that CD8alphaalpha binds to the protruding MHC alpha3 domain loop in an antibody-like manner. Comparison of mouse CD8alphaalpha/H-2Kb and human CD8alphaalpha/HLA-A2 complexes reveals shared as well as species-specific recognition features. In both species, coreceptor function apparently involves the participation of CD8 dimer in a bidentate attachment to an MHC class I molecule in conjunction with a T cell receptor without discernable conformational alteration of the peptide or MHC antigen-presenting platform.
About this Structure
1BQH is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb., Kern PS, Teng MK, Smolyar A, Liu JH, Liu J, Hussey RE, Spoerl R, Chang HC, Reinherz EL, Wang JH, Immunity. 1998 Oct;9(4):519-30. PMID:9806638 Page seeded by OCA on Fri May 2 11:49:54 2008
