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| <StructureSection load='2j64' size='350' side='right' scene='' caption='Human H-ficolin binding domain trimer complex with Ca+2 ion (PDB code [[2j64]]) '> | | <StructureSection load='2j64' size='350' side='right' scene='46/466464/Cv/1' caption='Human H-ficolin binding domain trimer complex with Ca+2 ion (PDB code [[2j64]]) '> |
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| == Function == | | == Function == |
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| Fn may play a role in inflammatory diseases, apoptosis, lupus, preeclampsia and IgA nephropathy<ref>PMID:19025118</ref>. | | Fn may play a role in inflammatory diseases, apoptosis, lupus, preeclampsia and IgA nephropathy<ref>PMID:19025118</ref>. |
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| | == Structural highlights == |
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| | <scene name='46/466464/Cv/2'>Human H-ficolin binding domain trimer</scene>. |
| </StructureSection> | | </StructureSection> |
| == 3D Structures of Ficolin == | | == 3D Structures of Ficolin == |
Revision as of 11:06, 21 February 2016
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Function
Ficolin (Fic) are defense proteins which belong to the innate immune system and recognize carbohydrate molecules[1]. 3 ficolins were identified in humans L-Fic or ficolin-2, H-Fic or ficolin-3 and M-Fic or ficolin-1.
Disease
Fn may play a role in inflammatory diseases, apoptosis, lupus, preeclampsia and IgA nephropathy[2].
Structural highlights
Human H-ficolin binding domain trimer.
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3D Structures of Ficolin
Updated on 21-February-2016
{"openlevels":0}
- H-ficolin
- 2j64 - hH-Fic binding domain - human
- 2j5z - hH-Fic binding domain + galactose
- 2j60 - hH-Fic binding domain + fucose
- 2j61 - hH-Fic binding domain + acetyl-glucosamine
- L-ficolin
- 2j3g, 4r9t - hL-Fic binding domain
- 2j0g – hL-Fic binding domain + N-acetyl-mannosamine
- 2j0h - hL-Fic binding domain + acetylcholine
- 4nyt - hL-Fic binding domain + phosphocholine
- 2j0y - hL-Fic binding domain + glucan
- 2j1g, 2j2p - hL-Fic binding domain + acetylcysteine
- 2j3f - hL-Fic binding domain + galactosamine
- 2j3o - hL-Fic binding domain + acetyl-glucosamine
- 4r9j - hL-Fic binding domain + glucosamine sulfate
- 2j3u - hL-Fic binding domain + galactose
- M-ficolin
- 2d39 – hM-Fic fibrinogen-like domain
- 2wnp - hM-Fic fibrinogen-like domain (mutant)
- 2jhh, 2jhm – hM-Fic C terminal
- 2jhi - hL-Mic C terminal + acetyl-galactosamine
- 2jhk - hL-Mic C terminal + acetyl-glucosamine
- 2jhl - hL-Mic C terminal + sialic acid
References
