Sandbox Reserved 1121: Difference between revisions
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=== PC binding site === | === PC binding site === | ||
PC stands for phosphocholine. It is a phospholipid in cell membranes and a plasma lipoproteins.<ref name="thompson">Thompson, D., Pepys, M. B., Wood, S. P. (1999), The physiological structure of human C-reactive protein and its complex with phosphocholine, Structure February 1999, 7:169–177.</ref> Phe-66 and Glu-81 are the two key residues that enable the binding of PC. <ref name="kumar"/> | PC stands for phosphocholine. It is a phospholipid in cell membranes and a plasma lipoproteins.<ref name="thompson">Thompson, D., Pepys, M. B., Wood, S. P. (1999), The physiological structure of human C-reactive protein and its complex with phosphocholine, Structure February 1999, 7:169–177.</ref> Phe-66 and Glu-81 are the two key residues that enable the binding of PC. <ref name="kumar"/> They interact with the choline function of PC, which therefore lies inside the PC-binding site. <ref name="agrawal"/> | ||
CRP binds the phosphocholine and other ligands in a Ca<sup>2+</sup>-dependent way. The PC-binding site is next to the Ca<sup>2+</sup>-binding sites on the same face of the CRP protein. Th PC-binding site is a hydrophobic pocket constituted by the residues Leu64, Phe66, Thr76 and the two Ca<sup>2+</sup>. The phosphate groupe of PC interacts by coordination with the two Ca<sup>2+</sup>. <ref name="agrawal"/> | |||
== Function == | == Function == | ||
