Sandbox Reserved 1121: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Lucile Guyot (talk | contribs) No edit summary |
Lucile Guyot (talk | contribs) No edit summary |
||
| Line 22: | Line 22: | ||
CRP binds the phosphocholine and other ligands in a Ca<sup>2+</sup>-dependent way. The PC-binding site is next to the Ca<sup>2+</sup>-binding sites on the same face of the CRP protein. The PC-binding site is a hydrophobic pocket constituted by the residues Leu64, Phe66, Thr76 and the two Ca<sup>2+</sup>. The phosphate groupe of PC interacts by coordination with the two Ca<sup>2+</sup>. | CRP binds the phosphocholine and other ligands in a Ca<sup>2+</sup>-dependent way. The PC-binding site is next to the Ca<sup>2+</sup>-binding sites on the same face of the CRP protein. The PC-binding site is a hydrophobic pocket constituted by the residues Leu64, Phe66, Thr76 and the two Ca<sup>2+</sup>. The phosphate groupe of PC interacts by coordination with the two Ca<sup>2+</sup>. | ||
CRP can also bind chromatin, histones, small nuclear robonucleoproteins nuclear envelop proteins and nucleosomes Ca<sup>2+</sup>-dependently <ref name="agrawal"/>. | CRP can also bind chromatin, histones, small nuclear robonucleoproteins nuclear envelop proteins and nucleosomes Ca<sup>2+</sup>-dependently <ref name="agrawal"/>. | ||
[[Image:Phosphocholine.PNG | thumb | Phosphocholine-binding site]] | |||
== Function == | == Function == | ||
