1bzy: Difference between revisions

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[[Image:1bzy.gif|left|200px]]
[[Image:1bzy.gif|left|200px]]


{{Structure
<!--
|PDB= 1bzy |SIZE=350|CAPTION= <scene name='initialview01'>1bzy</scene>, resolution 2.00&Aring;
The line below this paragraph, containing "STRUCTURE_1bzy", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)
|LIGAND= <scene name='pdbligand=IMU:PHOSPHORIC+ACID+MONO-[5-(2-AMINO-4-OXO-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-3,4-DIHYDROXY-PYRROLIDIN-2-YLMETHYL]+ESTER'>IMU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] </span>
or leave the SCENE parameter empty for the default display.
|GENE=  
-->
|DOMAIN=
{{STRUCTURE_1bzy| PDB=1bzy  | SCENE= }}  
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bzy OCA], [http://www.ebi.ac.uk/pdbsum/1bzy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bzy RCSB]</span>
}}


'''HUMAN HGPRTASE WITH TRANSITION STATE INHIBITOR'''
'''HUMAN HGPRTASE WITH TRANSITION STATE INHIBITOR'''
Line 33: Line 30:
[[Category: Shi, W.]]
[[Category: Shi, W.]]
[[Category: Tyler, P C.]]
[[Category: Tyler, P C.]]
[[Category: hgprt]]
[[Category: Hgprt]]
[[Category: immucillin]]
[[Category: Immucillin]]
[[Category: lesch-nyhan]]
[[Category: Lesch-nyhan]]
[[Category: magnesium]]
[[Category: Magnesium]]
[[Category: neighboring group participation]]
[[Category: Neighboring group participation]]
[[Category: oxocarbenium ion]]
[[Category: Oxocarbenium ion]]
[[Category: phosphoribosyltransferase]]
[[Category: Phosphoribosyltransferase]]
[[Category: pyrophosphate]]
[[Category: Pyrophosphate]]
[[Category: transition state]]
[[Category: Transition state]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:10:06 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:11:48 2008''

Revision as of 09:10, 2 May 2008

File:1bzy.gif


Drag the structure with the mouse to rotate
1bzy, resolution 2.00Å (default scene)
Ligands: IMU, MG, POP
Activity: Hypoxanthine phosphoribosyltransferase, with EC number 2.4.2.8
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



HUMAN HGPRTASE WITH TRANSITION STATE INHIBITOR


Overview

The structure of human HGPRT bound to the transition-state analog immucillinGP and Mg2+-pyrophosphate has been determined to 2.0 A resolution. ImmucillinGP was designed as a stable analog with the stereoelectronic features of the transition state. Bound inhibitor at the catalytic site indicates that the oxocarbenium ion of the transition state is stabilized by neighboring-group participation from MgPPi and O5'. A short hydrogen bond forms between Asp 137 and the purine ring analog. Two Mg2+ ions sandwich the pyrophosphate and contact both hydroxyls of the ribosyl analog. The transition-state analog is shielded from bulk solvent by a catalytic loop that moves approximately 25 A to cover the active site and becomes an ordered antiparallel beta-sheet.

About this Structure

1BZY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor., Shi W, Li CM, Tyler PC, Furneaux RH, Grubmeyer C, Schramm VL, Almo SC, Nat Struct Biol. 1999 Jun;6(6):588-93. PMID:10360366 Page seeded by OCA on Fri May 2 12:10:06 2008

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