Sandbox Reserved 1120: Difference between revisions
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The binding of SRY to DNA is specific. The DNA target site is a DNA octamer : | The binding of SRY to DNA is specific. The DNA target site is a DNA octamer : | ||
(5'-dGCACAAAC) | <center>(5'-dGCACAAAC) | ||
(5'-dGTTTGTGC) | (5'-dGTTTGTGC)</center> | ||
This sequenece is found in the promoters of genes expressed during the testicular development | This sequenece is found in the promoters of genes expressed during the testicular development | ||
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===Sex determining=== | ===Sex determining=== | ||
It acts like a sex determinator thanks to it transcriptionnal activity. It inhibits the developpement of female sex structure in th embryonnic individual. | It acts like a sex determinator thanks to it transcriptionnal activity. It inhibits the developpement of female sex structure in th embryonnic individual. | ||
It has been shown that SRY would be involved in the regulation of the renin-angiotensin system in mice. Indeed, sequence mutations of the protein lead to hypertension. | |||
Because the human's SRY organisation is very closed to he mouse's, it has been proposed that SRY would have the same function in human but it has not been studied directly. | |||
== Disease == | == Disease == | ||
