Sandbox Reserved 1124: Difference between revisions
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<Structure load='1GRI' size='400' frame='true' align='right' caption='Dimer of Grb2' scene='Insert optional scene name here' /> | <Structure load='1GRI' size='400' frame='true' align='right' caption='Dimer of Grb2' scene='Insert optional scene name here' /> | ||
== Introduction == | == 1 Introduction == | ||
Grb2 (Growth factor receptor-bound protein 2) is a connector protein that link grow factor receptors to the Ras signalling pathway. This protein implied in signal transduction pathways is essential for multiple cellular functions such as: embryonic development, cell proliferation... | Grb2 (Growth factor receptor-bound protein 2) is a connector protein that link grow factor receptors to the Ras signalling pathway. This protein implied in signal transduction pathways is essential for multiple cellular functions such as: embryonic development, cell proliferation... | ||
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== Structure == | == 2 Structure == | ||
Grb2 is a small protein of 217 residues with a molecular size of about 25 Da and composed of three remarkable domains : a single SH2 (Src Homology 2) domain (60 to 152 pdb) flanked by two conserved SH3 domains (respectively 1 to 58 and 156 to 215 pdb)<ref name="A">Gagani Athauda, Donald P Bottaro Atlas of Genetics and Cytogenetics in Oncology and Haematology (2007)[http://atlasgeneticsoncology.org/Genes/GRB2ID386ch17q25.html]</ref>. It has no catalytic domain. | Grb2 is a small protein of 217 residues with a molecular size of about 25 Da and composed of three remarkable domains : a single SH2 (Src Homology 2) domain (60 to 152 pdb) flanked by two conserved SH3 domains (respectively 1 to 58 and 156 to 215 pdb)<ref name="A">Gagani Athauda, Donald P Bottaro Atlas of Genetics and Cytogenetics in Oncology and Haematology (2007)[http://atlasgeneticsoncology.org/Genes/GRB2ID386ch17q25.html]</ref>. It has no catalytic domain. | ||
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===The N-Terminal SH3 domain=== | === 3 The N-Terminal SH3 domain=== | ||
<scene name='71/719865/Sh3_domain_1/1'>The N-terminal SH3 domains</scene> encompasse two three-stranded antiparallel β-sheets, one strand crosses the two sheets. This confers a barrel-like structure upon the domain. The first sheet contains the 3 following strands: S1 (Glu2-Ala5), S2 (Ile24-Lys26) and S6 (Ile53-Met55). The second sheet contains the strands S3 (Val27-Asn29), S4 (Trp36-Leu41) and S5 (Asp45-Ile48). The structure of this SH3 domain is stabilized by a high number of hydrophobic residues, which form the centre of the protein. | <scene name='71/719865/Sh3_domain_1/1'>The N-terminal SH3 domains</scene> encompasse two three-stranded antiparallel β-sheets, one strand crosses the two sheets. This confers a barrel-like structure upon the domain. The first sheet contains the 3 following strands: S1 (Glu2-Ala5), S2 (Ile24-Lys26) and S6 (Ile53-Met55). The second sheet contains the strands S3 (Val27-Asn29), S4 (Trp36-Leu41) and S5 (Asp45-Ile48). The structure of this SH3 domain is stabilized by a high number of hydrophobic residues, which form the centre of the protein. | ||
===The C-terminal SH3 domain=== | === 4 The C-terminal SH3 domain=== | ||
<scene name='71/719865/C-terminal_sh3_domains/1'>The C-terminal SH3 domains</scene> .... | <scene name='71/719865/C-terminal_sh3_domains/1'>The C-terminal SH3 domains</scene> .... | ||
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</StructureSection> | </StructureSection> | ||
== References == | == 5 References == | ||
<references/> | <references/> | ||
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