Complement C3: Difference between revisions
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<StructureSection load='2icf' size='340' side='right' caption='Structure of human glycosylated complement C3b α (magenta) and β (salmon) chains complex with protein CRIG ( | <StructureSection load='2icf' size='340' side='right' caption='Structure of human glycosylated complement C3b α (magenta) and β (salmon) chains complex with protein CRIG (cyan) and Ca+2 ion (green) (PDB code [[2icf]]).' scene='59/594590/Cv/1'> | ||
__TOC__ | __TOC__ | ||
== Function == | == Function == | ||
'''Complement C3''' (CC3) activates the complement system which is part of the immune response. CC3 is proteolytically cleaved by C3 convertase to C3a (residues 672-748) and C3b (residues 23-667, 749-1663). C3a is a mediator of local inflammatory processes. C3b binds covalently to cell surface carbohydrates or immune aggregates. Breakdown of C3b generates the fragment C3d (residues 996-1287) which binds to antigens enhancing their uptake by B cells. C3c is another C3b cleavage product residues: 23-664, 749-954, 1321-1663.<ref>PMID:11414361</ref> | '''Complement C3''' (CC3) activates the complement system which is part of the immune response. CC3 is proteolytically cleaved by C3 convertase to C3a (residues 672-748) and C3b (residues 23-667, 749-1663). C3a is a mediator of local inflammatory processes. C3b binds covalently to cell surface carbohydrates or immune aggregates. Breakdown of C3b generates the fragment C3d (residues 996-1287) which binds to antigens enhancing their uptake by B cells. C3c is another C3b cleavage product residues: 23-664, 749-954, 1321-1663.<ref>PMID:11414361</ref> | ||
<scene name='59/594590/Cv/2'>C3b α and β chains with protein CRIG and Ca+2 ion</scene>. | |||
<scene name='59/594590/Cv/3'>Ca+2 ion coordination site</scene>.(PDB code [[2icf]]) | |||
== Disease == | == Disease == | ||
