Sandbox Reserved 1121: Difference between revisions
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== Function == | == Function == | ||
CRP binds to PC located on the surface of bacteria that infected the organism. The resulting immune response is the | CRP is involved in the primary and innate host defense <ref name="Volanakis"/>. It binds to PC located on the surface of pathogens bacteria that infected the organism. The resulting immune response is the phagocytosis of PC-expressing bacteria <ref name="agrawal"/>. Moreover, apoptic and necrotic cells which belong to the host organism can be treated by the CRP resulting in a restoration of function in targeted tissues <ref name="Volanakis"/>. The CRP is therefore part of the acute phase response which is a rapid concentration variation of plasma proteins <ref name = "Alex">PMID: 12616974</ref>. | ||
When CRP is bind to a multivalent ligand, C1q is able to recognize it. This mechanism is initiated the C3 convertase assembly, which is an enzyme involved in the innate response. Furthermore,multiple pentamers have to be close to each other in order to realize this assembly <ref name="Volanakis"/>. | |||
== Biomedical interest == | == Biomedical interest == | ||
