Sandbox Reserved 1122: Difference between revisions
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{{Sandbox_Reserved_ESBS_2015}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | {{Sandbox_Reserved_ESBS_2015}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
==HUMAN BCL-2, ISOFORM1== | ==HUMAN BCL-2, ISOFORM1== | ||
<StructureSection load='1g5m' size='400' side='right' caption='HUMAN BCL-2, ISOFORM1' scene=''> | <StructureSection load='1g5m' size='400' side='right' caption='3D STRUCTURE OF HUMAN BCL-2, ISOFORM1 (from residue 3 to 207) BASED ON NMR SPECTROSCOPY' scene=''> | ||
Human BCL-2, isoform 1 is an oncoprotein of 239 residues regulating cell death (apoptosis), notably acting as an anti-apoptotic. It is encoded by the BCL2 gene located on the 18th chromosome (63.12-63.32 Mb). There are 2 isoforms of this protein (𝛼 and 𝛽), produced by alternative splicing, and which differ by 2 aminoacids (residues 96 (A→T) and 110 (R→G))(ref). Alteration of this protein is a caused of many cancers, and is also likely to be involved in schyzophrenia and autoimmunity. | Human BCL-2, isoform 1 is an oncoprotein of 239 residues regulating cell death (apoptosis), notably acting as an anti-apoptotic. It is encoded by the BCL2 gene located on the 18th chromosome (63.12-63.32 Mb). There are 2 isoforms of this protein (𝛼 and 𝛽), produced by alternative splicing, and which differ by 2 aminoacids (residues 96 (A→T) and 110 (R→G))(ref). Alteration of this protein is a caused of many cancers, and is also likely to be involved in schyzophrenia and autoimmunity. | ||
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Human BCL-2, isoform 1 is a 26kDa protein of 239 residues. The linear structure highlights 5 domains: <scene name='71/719863/Scenelucas/1'>BH4</scene> (10-30), | Human BCL-2, isoform 1 is a 26kDa protein of 239 residues. The linear structure highlights 5 domains: <scene name='71/719863/Scenelucas/1'>BH4</scene> (10-30), | ||
<scene name='71/719863/Scenebh3/2'>BH3</scene> (93-107), <scene name='71/719863/Scenebh1/1'>BH1</scene> (136-155), <scene name='71/719863/Scenebh2/1'>BH2</scene> (187-202) and a | <scene name='71/719863/Scenebh3/2'>BH3</scene> (93-107), <scene name='71/719863/Scenebh1/1'>BH1</scene> (136-155), <scene name='71/719863/Scenebh2/1'>BH2</scene> (187-202) and a | ||
transmembrane domain (218-239). It organizes as eight alpha-helices: from 11 to 25 (1) , from 93 to 107 (2), from 109 to 118 (3), from 126 to 137 (4), from 144-163 (5), from 169 to 184 (6), from 186 to 191 (7) and from 194 to 202(8). There are also 3 turns (32-34, 123-125, 138-140). The 3rd alpha-helix is a 3(10) helix, whereas BCL-XL 3rd helix is a normal alpha-helix. | |||
== Function == | == Function == | ||
