Calcium uptake protein 1: Difference between revisions
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MICU 1 is composed by differents domains : | MICU 1 is composed by differents domains : | ||
:- C helix region (or Coiled-coil domain) : this domain permits different interactions with other proteins (MCU/MICU2) and is required to assemble free Ca2+ with homohexamer. | :- C helix region (or Coiled-coil domain) : this domain permits different interactions with other proteins (MCU/MICU2) and is required to assemble free Ca2+ with homohexamer. | ||
:- Polybasic region : it’s a domain which permits protein-protein interactions | :- <scene name='72/723172/Polybasic_region/1'>Polybasic region</scene> : it’s a domain which permits protein-protein interactions | ||
:- <scene name='72/723172/Ef_domains/1'>EF-hand domains</scene> There are 2 of them. They are the most important domains in MICU1 protein because they contain the Ca2+ binding region and detect the concentration of calcium in the cell for activation of signalling. An EF-hand domain is a calcium sensor. An EF-hand domain is a helix loop helix structural domain that means that it is 2 alpha helices linked by a short loop region. Ca2+ ions are coordinated in this space thanks to ligands within the loop : in EF-1 residues concerning are Asp231, Asn233, Asp235, Glu237 and Glu242 and in EF-2 they are Asp421, Asp423, Asn425, Glu427 and Glu432. When Ca2+ binds itself to this domain, the protein changes its conformation to expose a domain that can interact with other proteins. | :- <scene name='72/723172/Ef_domains/1'>EF-hand domains</scene> There are 2 of them. They are the most important domains in MICU1 protein because they contain the Ca2+ binding region and detect the concentration of calcium in the cell for activation of signalling. An EF-hand domain is a calcium sensor. An EF-hand domain is a helix loop helix structural domain that means that it is 2 alpha helices linked by a short loop region. Ca2+ ions are coordinated in this space thanks to ligands within the loop : in EF-1 residues concerning are Asp231, Asn233, Asp235, Glu237 and Glu242 and in EF-2 they are Asp421, Asp423, Asn425, Glu427 and Glu432. When Ca2+ binds itself to this domain, the protein changes its conformation to expose a domain that can interact with other proteins. | ||
