Sandbox Reserved 1120: Difference between revisions
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== | == Diseases== | ||
=== Swyer syndrome (AKA XY gonadal dysgenis) :=== | === Swyer syndrome (AKA XY gonadal dysgenis) :=== | ||
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From the meiosis just described would also result an abnormal X chromosome, carrying the SRY gene. If the sperm cell owning this chromosome fecundates an ovule, the resulting newborn will have a XX karyotype but a male phenotype. This is called the « De La Chapelle syndrome ». In this case, the patient can either develop testis or both testis and ovarian tissues. As some epigenetic mechanisms can inactivate the X chromosome carrying SRY, this syndrome keeps most of the patients sterile.<ref>PMID: 4622299</ref> | From the meiosis just described would also result an abnormal X chromosome, carrying the SRY gene. If the sperm cell owning this chromosome fecundates an ovule, the resulting newborn will have a XX karyotype but a male phenotype. This is called the « De La Chapelle syndrome ». In this case, the patient can either develop testis or both testis and ovarian tissues. As some epigenetic mechanisms can inactivate the X chromosome carrying SRY, this syndrome keeps most of the patients sterile.<ref>PMID: 4622299</ref> | ||
===Hepatocellular carcinoma=== | |||
In the case on a hepatocellular carcinoma, it has been proven high expression levels of SRY helps cancer progression and poor patient survival. However, it still seems hepatocellular carcinoma is not most likely to develop in men.<ref>PMID: 25274159</ref> | |||
