Sandbox Reserved 1123: Difference between revisions
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== Function == | == Function == | ||
The HIV capsid is also called CA (for capsid) or p24. Its main role is to contain and protect the viral genome (RNA) and some enzymes (reverse transcriptase, integrase and protease). These proteins are indispensable because they are responsible of the structural assembly and organization of the virion. Indeed, p24 can interact with other viral proteins to assure the virion assembly and the RNA releasing. Furthermore, it can interact with host cell proteins during the viral cycle. <ref>[http://onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2009.07315.x/full The capsid protein of human immunodeficiency virus: interactions of HIV-1 capsid with host protein factors | |||
Authors : Anjali P.Mascarenhas, Karin Musier-Forsyth First published: 8 October 2009DOI: 10.1111/j.1742-4658.2009.07315.x]</ref> | |||
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=== Primary structure === | === Primary structure === | ||
CA proteins are composed of '''about 230 residues''' [4] and as we mentioned above they contain two domains: <scene name='71/719864/Ntd_capsid/1'>NTD </scene> (in green) and <scene name='71/719864/Ctd/2'>CTD </scene> (in yellow). These two domains are linked together thanks to a <scene name='71/719864/Flexible_linker/2'>Flexible linker </scene> (in orange). [1] | CA proteins are composed of '''about 230 residues''' [4] and as we mentioned above they contain two domains: <scene name='71/719864/Ntd_capsid/1'>NTD </scene> (in green) and <scene name='71/719864/Ctd/2'>CTD </scene> (in yellow). These two domains are linked together thanks to a <scene name='71/719864/Flexible_linker/2'>Flexible linker </scene> (in orange). [1] | ||
