Sandbox Reserved 1120: Difference between revisions

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hry OCA], [http://pdbe.org/1hry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hry RCSB], [http://www.ebi.ac.uk/pdbsum/1hry PDBsum]

<tr id='Molecular weight'><td class="sblockLbl"><b>Molecular weight</b><td class="sblockDat">≈23kDa

<tr id='Regulation'><td class="sblockLbl"><b>Regulation</b><td class="sblockDat">[https://en.wikipedia.org/wiki/Steroidogenic_factor_1 Sf1];[https://en.wikipedia.org/wiki/Sp1_transcription_factor Sp1] (2 binding site in the promoter of SRY : -150 and -13),[https://en.wikipedia.org/wiki/WT1 WT1] (2 binding sites in the promoter of SRY : -78 and -87)

The activation of sox 9 are done with protein SRY and another transcriptional factor: SF1 (steroidogenic factor 1). These transcriptional factors are bind in an enhancers called: TESCO (testis-specific enhancer of Sox9 core element). The fixation of transcriptional factor in enhancer provokes a curvature of DNA (90°C) allowing a stabilisation of the elongation complex on the SOX9 promoter. The SOX 9 protein activates the gene AMH (anti-mullerian hormone)<ref>[http://www.ebi.ac.uk/interpro/entry/IPR006799?q=AMH] </ref> allows the reduction of the channels of Müller in male. <ref>Harley VR, Clarkson MJ, Argentaro A. The Molecular Action and Regulation of the Testis-Determining Factors, SRY (Sex-Determining Region on the Y Chromosome) and SOX9 [SRY-Related High-Mobility Group (HMG) Box 9]. Endocr Rev. 2003 Aug 1;24(4):466–87. [http://press.endocrine.org/doi/10.1210/er.2002-0025?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&]</ref>

:It has been shown that SRY would be involved in the regulation of the renin-angiotensin system in mice. Indeed, sequence mutations of the protein lead to hypertension.