Sandbox Reserved 1120: Difference between revisions

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<tr><td colspan='2'>The SRY protein is a 204 residues long monomeric polypeptide. It is encoded by the [https://en.wikipedia.org/wiki/Testis_determining_factor testis-determining sex gene] and is involved in the sex determination in mammels by being responsible for the gonadogenesis thus the male sexual developement. It is the HMG-box that gives to the protein its ability to bind DNA by its minor groove. <ref>PMID: 9626701</ref></td></tr>
<tr><td colspan='2'>The SRY protein is a 204 residues-long monomeric polypeptide. It is encoded by the SRY gene and is involved in the sex determination in mammals by being responsible for the gonadogenesis and so the male sexual development. It is the HMG-box that gives to the protein its ability to bind DNA by its minor groove. <ref>PMID: 9626701</ref></td></tr>


<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hrz|1hrz]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hrz|1hrz]]</td></tr>
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<tr id='Molecular weight'><td class="sblockLbl"><b>Molecular weight</b><td class="sblockDat">≈23kDa
<tr id='Molecular weight'><td class="sblockLbl"><b>Molecular weight</b><td class="sblockDat">≈23kDa
<tr id='DNA target sequence'><td class="sblockLbl"><b>DNA target sequence</b><td class="sblockDat">(5'-dGCACAAAC)
<tr id='DNA target sequence'><td class="sblockLbl"><b>DNA target sequence</b><td class="sblockDat">(5'-dGCACAAAC)
<tr id='Regulation'><td class="sblockLbl"><b>Regulation</b><td class="sblockDat">[https://en.wikipedia.org/wiki/Steroidogenic_factor_1 Sf1];[https://en.wikipedia.org/wiki/Sp1_transcription_factor Sp1] (2 binding site in the promoter of SRY : -150 and -13),[https://en.wikipedia.org/wiki/WT1 WT1] (2 binding sites in the promoter of SRY : -78 and -87)
<tr id='Regulation'><td class="sblockLbl"><b>Regulation</b><td class="sblockDat">[https://en.wikipedia.org/wiki/Steroidogenic_factor_1 Sf1];[https://en.wikipedia.org/wiki/Sp1_transcription_factor Sp1] (binding site in the promoter of SRY : -150),[https://en.wikipedia.org/wiki/WT1 WT1] (binding site in the promoter of SRY : -87)
<tr id='Role'><td class="sblockLbl"><b>Role</b><td class="sblockDat">Transcription factor
<tr id='Role'><td class="sblockLbl"><b>Role</b><td class="sblockDat">Transcription factor
<tr id='Genes targeted'><td class="sblockLbl"><b>Genes targeted</b><td class="sblockDat">Sox9
<tr id='Genes targeted'><td class="sblockLbl"><b>Genes targeted</b><td class="sblockDat">SOX9


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During the next decades, a few theories were in competition. In 1921, Calvin Bridges's works on ''Drosophila melanogaster'' seemed to reveal that male characters acquisition is due to a genic balance between the genes contained in the X chromosome and those contained in the autosomes<ref>PMID: 17769897</ref>.
During the next decades, a few theories were in competition. In 1921, Calvin Bridges's works on ''Drosophila melanogaster'' seemed to reveal that male characters acquisition is due to a genic balance between the genes contained in the X chromosome and those contained in the autosomes<ref>PMID: 17769897</ref>.
In 1930, Ronald Fisher introduced the first Y-based control of sex theory by proposing two different models : either all the genes responsible for the male characters are located on the Y chromosome or there is a Y-located gene which regulates the expression of genes elsewhere in the genome<ref>PMID: 3046910</ref>.
In 1930, Ronald Fisher introduced the first Y-based control of sex theory by proposing two different models : either all the genes responsible for the male characters are located on the Y chromosome or there is a Y-located gene which regulates the expression of genes elsewhere in the genome<ref>PMID: 3046910</ref>.
As Alfred Jost had shown the testosterone produced by the testis is responsible for the entire male phenotype acquisition<ref>PMID: 4805859</ref>, in 1988, Peter Neville Goodfellow proposed that there is a gene (''TDF'' in human, ''Tdy'' in mice)  on the Y chromosome which drives the development of the testis.<ref>PMID: 3046910</ref> In 1990, Goodfellow's hypothesis was validated with the discovery of ''Tdy'''s localisation. This gene's product (expressed during the male gonadal development) owns an amino-acid motif showing homology to other known or putative DNA-binding domains. ''Tdy'' is therefore a transcriptional factor<ref>PMID: 2374589</ref>. The same year, the human ''SRY'' gene (accepted later as the ''TDF'') was discovered<ref>PMID: 1695712</ref>.  
As Alfred Jost had shown the testosterone produced by the testis is responsible for the entire male phenotype acquisition<ref>PMID: 4805859</ref>, Peter Neville Goodfellow proposed in 1988, that there is a gene (''TDF'' in human, ''Tdy'' in mice)  on the Y chromosome which drives the development of the testis.<ref>PMID: 3046910</ref> In 1990, Goodfellow's hypothesis was validated with the discovery of ''Tdy'''s localisation. This gene's product (expressed during the male gonadal development) owns an amino-acid motif showing homology to other known or putative DNA-binding domains. ''Tdy'' is therefore a transcriptional factor<ref>PMID: 2374589</ref>. The same year, the human ''SRY'' gene (accepted later as the ''TDF'') was discovered<ref>PMID: 1695712</ref>.  
Three dimensional structure of the SRY protein was determined in 1995 using NMR spectroscopy<ref>PMID: 7774012</ref>
Three dimensional structure of the SRY protein was determined in 1995 using NMR spectroscopy<ref>PMID: 7774012</ref>


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