Sandbox Reserved 1122: Difference between revisions
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=== Inhibition of autophagy === | === Inhibition of autophagy === | ||
Autophagy is a very conserved event during which different cytoplasmic organelles and other structures are delivered to the lysosome where they are recycled. This mechanism may enhance cell survival because it is responsible for getting rid of intracellular pathogens, toxic molecules or damaged organelles. On the other hand, if autophagy is excessive, it may lead to the cell death. This process has many regulatory pathways including the interaction between the autophagy protein Beclin 1 and Bcl-2. Only the Bcl-2 which is localized in the ER is capable to bind Beclin 1 through its <scene name='71/719863/Scenebh1/1'>BH1</scene> and name='71/719863/Scenebh2/1'>BH2</scene> domains. Normally Beclin 1 forms a complex with hVps34 (Class III PI3K). This complex is important for the localization of other autophagy proteins in the lysosome membrane. It is one of the first steps in the autophagosome formation and it can be inhibited by Bcl-2. At normal conditions this interaction is minor but it increases when the cell is starving. Thus, Bcl-2 prevents starvation-induced autophagy. <ref> [http://www.cell.com/cell/fulltext/S0092-8674(05)00692-6 Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy] </ref> | Autophagy is a very conserved event during which different cytoplasmic organelles and other structures are delivered to the lysosome where they are recycled. This mechanism may enhance cell survival because it is responsible for getting rid of intracellular pathogens, toxic molecules or damaged organelles. On the other hand, if autophagy is excessive, it may lead to the cell death. This process has many regulatory pathways including the interaction between the autophagy protein Beclin 1 and Bcl-2. Only the Bcl-2 which is localized in the ER is capable to bind Beclin 1 through its <scene name='71/719863/Scenebh1/1'>BH1</scene> and <scene name='71/719863/Scenebh2/1'>BH2</scene> domains. Normally Beclin 1 forms a complex with hVps34 (Class III PI3K). This complex is important for the localization of other autophagy proteins in the lysosome membrane. It is one of the first steps in the autophagosome formation and it can be inhibited by Bcl-2. At normal conditions this interaction is minor but it increases when the cell is starving. Thus, Bcl-2 prevents starvation-induced autophagy. <ref> [http://www.cell.com/cell/fulltext/S0092-8674(05)00692-6 Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy] </ref> | ||
== Diseases == | == Diseases == | ||
