Sandbox Reserved 1124: Difference between revisions

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<scene name='71/719865/C-terminal_sh3_domains/1'>The C-terminal SH3 domain</scene> ~~improves the overall stability of the Grb2-SOS complex.<ref >DOI: http://dx.doi.org/10.1016/1074-5521(95)90080-2</ref>~~

<scene name='71/719865/C-terminal_sh3_domains/1'>The C-terminal SH3 domain</scene> goes from the amino acid 156 to 215. The role of this domain is little known. But it has been shown that, for a stable complex formation, the Ct SH3 domain has to recognize a 13 residues sequence with the following motif: P-x-x-x-R-x-x-K-P. Sos contains this sequence, as well as Gab1, which also binds to Grb2. The interaction of Grb2 with Gab1 has been demonstrated with precipitation experiments. ref

~~Moreover, this C-Terminal domain specifically binds to proteins with a P-X-I/L/V-D/N-R-X-X-K-P motif such as Gab1.<ref>DOI:10.1016/S0960-9822(02)01038-2</ref>~~

In the Ras pathway, the Ct SH3 domain improves the overall stability of the Grb2-SOS complex.<ref >DOI: http://dx.doi.org/10.1016/1074-5521(95)90080-2</ref>

~~The C-terminal SH3 domain~~ goes from the amino acid 156 to 215. The role of this domain is little known. But it has been shown that, for a stable complex formation, the Ct SH3 domain has to recognize a 13 residues sequence with the following motif: P-x-x-x-R-x-x-K-P. Sos contains this sequence, as well as Gab1, which also binds to Grb2. The interaction of Grb2 with Gab1 has been demonstrated with precipitation experiments.

Sandbox Reserved 1124: Difference between revisions

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@@ Line 65: / Line 65: @@
-<scene name='71/719865/C-terminal_sh3_domains/1'>The C-terminal SH3 domain</scene> improves the overall stability of the Grb2-SOS complex.<ref >DOI: http://dx.doi.org/10.1016/1074-5521(95)90080-2</ref>
+<scene name='71/719865/C-terminal_sh3_domains/1'>The C-terminal SH3 domain</scene> goes from the amino acid 156 to 215. The role of this domain is little known. But it has been shown that, for a stable complex formation, the Ct SH3 domain has to recognize a 13 residues sequence with the following motif: P-x-x-x-R-x-x-K-P. Sos contains this sequence, as well as Gab1, which also binds to Grb2. The interaction of Grb2 with Gab1 has been demonstrated with precipitation experiments. ref
-Moreover, this C-Terminal domain specifically binds to proteins with a P-X-I/L/V-D/N-R-X-X-K-P motif such as Gab1.<ref>DOI:10.1016/S0960-9822(02)01038-2</ref>
+In the Ras pathway, the Ct SH3 domain improves the overall stability of the Grb2-SOS complex.<ref >DOI: http://dx.doi.org/10.1016/1074-5521(95)90080-2</ref>
-The C-terminal SH3 domain goes from the amino acid 156 to 215. The role of this domain is little known. But it has been shown that, for a stable complex formation, the Ct SH3 domain has to recognize a 13 residues sequence with the following motif: P-x-x-x-R-x-x-K-P. Sos contains this sequence, as well as Gab1, which also binds to Grb2. The interaction of Grb2 with Gab1 has been demonstrated with precipitation experiments.