Sandbox Reserved 1121: Difference between revisions
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=== Phosphocholine-binding site === | === Phosphocholine-binding site === | ||
[[Image:Phosphocholine.PNG | thumb | PC and Ca<sup>2+</sup>-binding site <ref name="PyMol"/>]] | [[Image:Phosphocholine.PNG | thumb | PC and Ca<sup>2+</sup>-binding site <ref name="PyMol"/>]] | ||
Phosphocholine(PC) is a phospholipid in cell membranes and a plasma lipoprotein <ref name="Thompson"/>. The PC-binding site is a hydrophobic pocket constituted by the residues Leu64, Phe66, Thr76 and the two Ca<sup>2+</sup> <ref name="agrawal"/><ref name="Volanakis"/>. This residues are very important because if one of them is mutated into an other, the avidity is significantly reduced <ref name="Volanakis"/>. | Phosphocholine (PC) is a phospholipid found in cell membranes and a plasma lipoprotein <ref name="Thompson"/>. The PC-binding site is a hydrophobic pocket constituted by the residues Leu64, Phe66, Thr76 and the two Ca<sup>2+</sup> <ref name="agrawal"/><ref name="Volanakis"/>. This residues are very important because if one of them is mutated into an other, the avidity is significantly reduced <ref name="Volanakis"/>. | ||
Two of the oxygens of the phosphate group directly co-ordinate with the two Ca<sup>2+</sup> bound on the CRP <ref name="Volanakis"/>, leaving the third oxygen pointing away from the binding sites <ref name="Thompson"/>.The choline group rests within the hydrophobic pocket. | Two of the oxygens of the phosphate group directly co-ordinate with the two Ca<sup>2+</sup> bound on the CRP <ref name="Volanakis"/>, leaving the third oxygen pointing away from the binding sites <ref name="Thompson"/>.The choline group rests within the hydrophobic pocket. | ||
