Sandbox Reserved 1124: Difference between revisions

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	In Alzheimer's disease, Grb2 and ~~SOS1 are disrupted which mean that they both can play a role~~ in ~~this disease. For Grb2~~, it is its ~~cellular distribution that is altered~~. <ref>PMID: ~~9878757~~</ref>		Grb2 is implied in Alzheimer's disease. It is an adaptor protein of AbetaPP (amyloid-beta protein precursor), a protein matured by proteases along the endosomal lysosomal pathway. In Alzheimer's disease patient neurons, Grb2 is overexpressed and concentrates in the neuronal cell bodies and more precisely in late endosomes, bringing AbetaPP proteins with it. The sequestration of AbetaPP in late endosomes avoids its release and causes an abnormal increasing of its intracellular concentration.<ref>PMID: 20164575</ref>


	== References ==		== References ==

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