Sandbox Reserved 1125: Difference between revisions
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*is a hydrolase: it hydrolyzes covalent bonds | *is a hydrolase: it hydrolyzes covalent bonds | ||
*is an endopeptidase: it cleaves peptide bond | *is an endopeptidase: it cleaves peptide bond | ||
*cleaves interstitial collagens in the triple helical domain (at a site about three-fourths away from the N-terminus) | *cleaves interstitial [http://proteopedia.org/wiki/index.php/Collagen collagens] in the triple helical domain (at a site about three-fourths away from the N-terminus) | ||
The metalloendopeptidase activity is defined by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.<ref>[http://www.ebi.ac.uk/QuickGO/GTerm?id=GO:0004222#info=4 "Metalloendopeptidase activity"]</ref> | The metalloendopeptidase activity is defined by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.<ref>[http://www.ebi.ac.uk/QuickGO/GTerm?id=GO:0004222#info=4 "Metalloendopeptidase activity"]</ref> | ||
The difference between this classification and EC 3.4.24.7 is that this enzyme cleaves type III collagen more slowly than type I. | The difference between this classification and EC 3.4.24.7 is that this enzyme cleaves type III collagen more slowly than type I. | ||
