Sandbox Reserved 1121: Difference between revisions

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When CRP is bind to a multivalent ligand, C1q is able to recognize it. This mechanism is initiated the C3 convertase assembly, which is an enzyme involved in the innate response. Furthermore, multiple pentamers have to be close to each other in order to realize this assembly <ref name="Volanakis"/>.

== Biomedical interest ==

It is known that CRP rate increase rapidly and markedly during inflammatory states. However, minor CRP elevation has been related with future major cardiovascular events. Indeed, studies have shown that a slightly elevated CRP plasma level (between 3 and 10 µg/mL) is associated with a risk of developing cardiovascular disease, metabolic syndrome and colon cancer <ref name="Black"/>.

Nevertheless, minor increase of CRP levels is not necessarly associated with inflammation by cou:d be linked to several genetic polymorphisms of the CRP and other gens, ethnicity, various dietary patterns and obesity <ref name="Black"/>.

Futhermore, CRP might play a role in the pathogenesis of atherosclerosis, but the exact role of CRP in atherosclerosis is not known. It was found that CRP binds the phosphocholine of oxidized low density lipoproteins, up-regulates the expression of adhesion molecules in endothelial cells, increases low density lipoprotein uptake into macrophages, inhibits endothelial nitric-oxide synthase expression in aortic endothelial cells and increases plasminogen activator inhibitor-1 expression and activity <ref name="Black"/>. Transgenic mice deficient in apolipoprotein E and expressing high levels of CRP display a modest acceleration in aortic atherosclerosis <ref name="Black"/>.

== References ==

Sandbox Reserved 1121: Difference between revisions

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@@ Line 39: / Line 39: @@
 When CRP is bind to a multivalent ligand, C1q is able to recognize it. This mechanism is initiated the C3 convertase assembly, which is an enzyme involved in the innate response. Furthermore, multiple pentamers have to be close to each other in order to realize this assembly <ref name="Volanakis"/>.
+== Biomedical interest ==
+It is known that CRP rate increase rapidly and markedly during inflammatory states. However, minor CRP elevation has been related with future major cardiovascular events. Indeed, studies have shown that a slightly elevated CRP plasma level (between 3 and 10 µg/mL) is associated with a risk of developing cardiovascular disease, metabolic syndrome and colon cancer <ref name="Black"/>.
+Nevertheless, minor increase of CRP levels is not necessarly associated with inflammation by cou:d be linked to several genetic polymorphisms of the CRP and other gens, ethnicity, various dietary patterns and obesity <ref name="Black"/>.
+Futhermore, CRP might play a role in the pathogenesis of atherosclerosis, but the exact role of CRP in atherosclerosis is not known. It was found that CRP binds the phosphocholine of oxidized low density lipoproteins, up-regulates the expression of adhesion molecules in endothelial cells, increases low density lipoprotein uptake into macrophages, inhibits endothelial nitric-oxide synthase expression in aortic endothelial cells and increases plasminogen activator inhibitor-1 expression and activity <ref name="Black"/>. Transgenic mice deficient in apolipoprotein E and expressing high levels of CRP display a modest acceleration in aortic atherosclerosis <ref name="Black"/>.
 == References ==
 <references/>