Sandbox Reserved 1121: Difference between revisions
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When CRP is bind to a multivalent ligand, C1q is able to recognize it. This mechanism is initiated the C3 convertase assembly, which is an enzyme involved in the innate response. Furthermore, multiple pentamers have to be close to each other in order to realize this assembly <ref name="Volanakis"/>. | When CRP is bind to a multivalent ligand, C1q is able to recognize it. This mechanism is initiated the C3 convertase assembly, which is an enzyme involved in the innate response. Furthermore, multiple pentamers have to be close to each other in order to realize this assembly <ref name="Volanakis"/>. | ||
== Biomedical | == Biomedical consideration == | ||
It is known that CRP rate increase rapidly and markedly during inflammatory states. However, minor CRP elevation has been related with future major cardiovascular events. Indeed, studies have shown that a slightly elevated CRP plasma level (between 3 and 10 µg/mL) is associated with a risk of developing cardiovascular disease, metabolic syndrome and colon cancer <ref name="Black"/>. | It is known that CRP rate increase rapidly and markedly during inflammatory states. However, minor CRP elevation has been related with future major cardiovascular events. Indeed, studies have shown that a slightly elevated CRP plasma level (between 3 and 10 µg/mL) is associated with a risk of developing cardiovascular disease, metabolic syndrome and colon cancer <ref name="Black"/>. | ||
