G12SecL02Tpc3: Difference between revisions
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==Introduction== | ==Introduction== | ||
''Borrelia burgdorferi'' is a gram-negative spirochete that is the causative agent of Lyme disease. It’s transmitted to humans through hard-bodied ticks of the genus Ixodes. In order for this microbe to survive and proliferate in its various environments, it possesses many different lipid anchored outer surface proteins, including OspB. | ''Borrelia burgdorferi'' is a gram-negative spirochete that is the causative agent of Lyme disease. It’s transmitted to humans through hard-bodied ticks of the genus Ixodes. In order for this microbe to survive and proliferate in its various environments, it possesses many different lipid anchored outer surface proteins, including OspB. | ||
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Examining the global dynamics of the antigen + Fab by NMR methods have shown that the effects of binding can be propagated to regions of the antigen that are distant to the epitope, which would be critical to the auto proteolytic removal of strands 1-4. | Examining the global dynamics of the antigen + Fab by NMR methods have shown that the effects of binding can be propagated to regions of the antigen that are distant to the epitope, which would be critical to the auto proteolytic removal of strands 1-4. | ||
