5hs3: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5hs3 ~~is ON HOLD~~

==Human thymidylate synthase complexed with dUMP and 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol==

~~Authors~~: ~~Chen, D~~.~~, Almqvist, H~~.~~, Axelsson, H~~.~~, Jafari, R~~.~~, Mateus, A~~.~~, Haraldsson, M~~.~~, Larsson, A~~.~~, Artursson, P~~.~~, Molina, D.M., Lundback, T., Nordlund, P~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[5hs3]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HS3 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HS3 FirstGlance].

~~Description~~: ~~Human thymidylate synthase complexed with dUMP and~~ 3-~~amino~~-2-~~benzoyl~~-4-~~methylthieno~~[2,3-b]~~pyridin~~-6-ol

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=KI3:3-AMINO-2-BENZOYL-4-METHYLTHIENO[2,3-B]PYRIDIN-6-OL'>KI3</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </td></tr>

[[Category: ~~Molina~~, D.M]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hs3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hs3 OCA], [http://pdbe.org/5hs3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hs3 RCSB], [http://www.ebi.ac.uk/pdbsum/5hs3 PDBsum]</td></tr>

[[Category: ~~Nordlund~~, P]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN]] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Thymidylate synthase]]

[[Category: Almqvist, H]]

[[Category: Artursson, P]]

[[Category: Axelsson, H]]

[[Category: Chen, D]]

[[Category: Haraldsson, M]]

[[Category: Jafari, R]]

[[Category: Larsson, A]]

[[Category: Lundback, T]]

~~[[Category: Artursson, P]]~~

[[Category: Mateus, A]]

[[Category: ~~Haraldsson~~, M]]

[[Category: Molina, D M]]

[[Category: ~~Jafari, R]]~~

[[Category: Nordlund, P]]

~~[[Category: Axelsson~~, H]]

[[Category: Nhibitor]]

[[Category: ~~Almqvist, H~~]]

[[Category: Transferase-transferase inhibitor complex]]

[[Category: ~~Chen, D~~]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5hs3 is ON HOLD
+==Human thymidylate synthase complexed with dUMP and 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol==
+<StructureSection load='5hs3' size='340' side='right' caption='[[5hs3]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
-Authors: Chen, D., Almqvist, H., Axelsson, H., Jafari, R., Mateus, A., Haraldsson, M., Larsson, A., Artursson, P., Molina, D.M., Lundback, T., Nordlund, P.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5hs3]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HS3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HS3 FirstGlance]. <br>
-Description: Human thymidylate synthase complexed with dUMP and 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KI3:3-AMINO-2-BENZOYL-4-METHYLTHIENO[2,3-B]PYRIDIN-6-OL'>KI3</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
-[[Category: Molina, D.M]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hs3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hs3 OCA], [http://pdbe.org/5hs3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hs3 RCSB], [http://www.ebi.ac.uk/pdbsum/5hs3 PDBsum]</span></td></tr>
-[[Category: Nordlund, P]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN]] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Thymidylate synthase]]
+[[Category: Almqvist, H]]
+[[Category: Artursson, P]]
+[[Category: Axelsson, H]]
+[[Category: Chen, D]]
+[[Category: Haraldsson, M]]
+[[Category: Jafari, R]]
 [[Category: Larsson, A]]
 [[Category: Lundback, T]]
-[[Category: Artursson, P]]
 [[Category: Mateus, A]]
-[[Category: Haraldsson, M]]
+[[Category: Molina, D M]]
-[[Category: Jafari, R]]
+[[Category: Nordlund, P]]
-[[Category: Axelsson, H]]
+[[Category: Nhibitor]]
-[[Category: Almqvist, H]]
+[[Category: Transferase-transferase inhibitor complex]]
-[[Category: Chen, D]]