1ca6: Difference between revisions

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[[Image:1ca6.gif|left|200px]]
[[Image:1ca6.gif|left|200px]]


{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ca6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ca6 OCA], [http://www.ebi.ac.uk/pdbsum/1ca6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ca6 RCSB]</span>
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'''INTERCALATION SITE OF HYPERTHERMOPHILE CHROMOSOMAL PROTEIN SSO7D/SAC7D BOUND TO DNA'''
'''INTERCALATION SITE OF HYPERTHERMOPHILE CHROMOSOMAL PROTEIN SSO7D/SAC7D BOUND TO DNA'''
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[[Category: Su, S.]]
[[Category: Su, S.]]
[[Category: Wang, A H.J.]]
[[Category: Wang, A H.J.]]
[[Category: chromosomal protein]]
[[Category: Chromosomal protein]]
[[Category: dna binding]]
[[Category: Dna binding]]
[[Category: hyperthermophile]]
[[Category: Hyperthermophile]]
[[Category: sac7d]]
[[Category: Sac7d]]
[[Category: sso7d]]
[[Category: Sso7d]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:31:04 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:17:45 2008''

Revision as of 09:31, 2 May 2008

File:1ca6.gif

Template:STRUCTURE 1ca6

INTERCALATION SITE OF HYPERTHERMOPHILE CHROMOSOMAL PROTEIN SSO7D/SAC7D BOUND TO DNA


Overview

Sso7d and Sac7d are two small chromatin proteins from the hyperthermophilic archaeabacterium Sulfolobus solfataricus and Sulfolobus acidocaldarius, respectively. The crystal structures of Sso7d-GTGATCGC, Sac7d-GTGATCGC and Sac7d-GTGATCAC have been determined and refined at 1.45 A, 2.2 A and 2.2 A, respectively, to investigate the DNA binding property of Sso7d/Sac7d in the presence of a T-G mismatch base-pair. Detailed structural analysis revealed that the intercalation site includes the T-G mismatch base-pair and Sso7d/Sac7d bind to that mismatch base-pair in a manner similar to regular DNA. In the Sso7d-GTGATCGC complex, a new inter-strand hydrogen bond between T2O4 and C14N4 is formed and well-order bridging water molecules are found. The results suggest that the less stable DNA stacking site involving a T-G mismatch may be a preferred site for protein side-chain intercalation.

About this Structure

1CA6 is a Single protein structure of sequence from Sulfolobus acidocaldarius. Full crystallographic information is available from OCA.

Reference

Crystal structures of the chromosomal proteins Sso7d/Sac7d bound to DNA containing T-G mismatched base-pairs., Su S, Gao YG, Robinson H, Liaw YC, Edmondson SP, Shriver JW, Wang AH, J Mol Biol. 2000 Oct 27;303(3):395-403. PMID:11031116 Page seeded by OCA on Fri May 2 12:31:04 2008

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