1cd9: Difference between revisions
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'''2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR''' | '''2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR''' | ||
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[[Category: Okamoto, T.]] | [[Category: Okamoto, T.]] | ||
[[Category: Ota, Y.]] | [[Category: Ota, Y.]] | ||
[[Category: | [[Category: Class1 cytokine]] | ||
[[Category: | [[Category: Hematopoietic receptor]] | ||
[[Category: | [[Category: Signal transduction]] | ||
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Revision as of 09:36, 2 May 2008
2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR
Overview
Granulocyte colony-stimulating factor (GCSF) is the principal growth factor regulating the maturation, proliferation and differentiation of the precursor cells of neutrophilic granulocytes and is used to treat neutropenia. GCSF is a member of the long-chain subtype of the class 1 cytokine superfamily, which includes growth hormone, erythropoietin, interleukin 6 and oncostatin M. Here we have determined the crystal structure of GCSF complexed to the BN-BC domains, the principal ligand-binding region of the GCSF receptor (GCSFR). The two receptor domains form a complex in a 2:2 ratio with the ligand, with a non-crystallographic pseudo-twofold axis through primarily the interdomain region and secondarily the BC domain. This structural view of a gp130-type receptor-ligand complex presents a new molecular basis for cytokine-receptor recognition.
About this Structure
1CD9 is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
Reference
Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme., Aritomi M, Kunishima N, Okamoto T, Kuroki R, Ota Y, Morikawa K, Nature. 1999 Oct 14;401(6754):713-7. PMID:10537111 Page seeded by OCA on Fri May 2 12:36:07 2008
