1cgp: Difference between revisions

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[[Image:1cgp.gif|left|200px]]
[[Image:1cgp.gif|left|200px]]


{{Structure
<!--
|PDB= 1cgp |SIZE=350|CAPTION= <scene name='initialview01'>1cgp</scene>, resolution 3.000&Aring;
The line below this paragraph, containing "STRUCTURE_1cgp", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)
|LIGAND= <scene name='pdbligand=CMP:ADENOSINE-3&#39;,5&#39;-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY=  
or leave the SCENE parameter empty for the default display.
|GENE=  
-->
|DOMAIN=
{{STRUCTURE_1cgp| PDB=1cgp  | SCENE= }}  
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cgp OCA], [http://www.ebi.ac.uk/pdbsum/1cgp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cgp RCSB]</span>
}}


'''CATABOLITE GENE ACTIVATOR PROTEIN (CAP)/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE'''
'''CATABOLITE GENE ACTIVATOR PROTEIN (CAP)/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE'''
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[[Category: Shields, G C]]
[[Category: Shields, G C]]
[[Category: Steitz, T A.]]
[[Category: Steitz, T A.]]
[[Category: double helix]]
[[Category: Double helix]]
[[Category: protein-dna complex]]
[[Category: Protein-dna complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:43:06 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:21:31 2008''

Revision as of 09:43, 2 May 2008

File:1cgp.gif

Template:STRUCTURE 1cgp

CATABOLITE GENE ACTIVATOR PROTEIN (CAP)/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE


Overview

The 3 angstrom resolution crystal structure of the Escherichia coli catabolite gene activator protein (CAP) complexed with a 30-base pair DNA sequence shows that the DNA is bent by 90 degrees. This bend results almost entirely from two 40 degrees kinks that occur between TG/CA base pairs at positions 5 and 6 on each side of the dyad axis of the complex. DNA sequence discrimination by CAP derives both from sequence-dependent distortion of the DNA helix and from direct hydrogen-bonding interactions between three protein side chains and the exposed edges of three base pairs in the major groove of the DNA. The structure of this transcription factor--DNA complex provides insights into possible mechanisms of transcription activation.

About this Structure

1CGP is a Single protein structure of sequence from Escherichia coli. The following page contains interesting information on the relation of 1CGP with [Catabolite Activator Protein]. Full crystallographic information is available from OCA.

Reference

Crystal structure of a CAP-DNA complex: the DNA is bent by 90 degrees., Schultz SC, Shields GC, Steitz TA, Science. 1991 Aug 30;253(5023):1001-7. PMID:1653449 Page seeded by OCA on Fri May 2 12:43:06 2008

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