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'''DNA-BINDING MECHANISM OF THE MONOMERIC ORPHAN NUCLEAR RECEPTOR NGFI-B''' | '''DNA-BINDING MECHANISM OF THE MONOMERIC ORPHAN NUCLEAR RECEPTOR NGFI-B''' | ||
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[[Category: Meinke, G.]] | [[Category: Meinke, G.]] | ||
[[Category: Sigler, P B.]] | [[Category: Sigler, P B.]] | ||
[[Category: | [[Category: Early immediate response gene product]] | ||
[[Category: | [[Category: Minor groove interaction]] | ||
[[Category: | [[Category: Monomeric protein-dna complex]] | ||
[[Category: | [[Category: Orphan nuclear receptor]] | ||
[[Category: | [[Category: Protein/dna]] | ||
[[Category: | [[Category: Transcription factor]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:46:36 2008'' | |||
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Revision as of 09:46, 2 May 2008
DNA-BINDING MECHANISM OF THE MONOMERIC ORPHAN NUCLEAR RECEPTOR NGFI-B
Overview
The 2.7 A X-ray crystal structure of the DNA-binding domain (DBD) of the orphan nuclear receptor, nerve growth factor-induced-B (NGFI-B), complexed to its high-affinity DNA target, represents the first structure analysis of a nuclear receptor DBD bound as a monomer to DNA. The structure of the core DBD and its interactions with the major groove of the DNA are similar to previously crystallographically solved DBD-DNA complexes in this superfamily; however, residues C-terminal to this core form a separate and unique substructure that interacts extensively and in a sequence-specific way with the minor groove of its DNA target, in particular with the characteristic 3 A-T base-pair identity element that extends 5' to the usual nuclear receptor half-site (AGGTCA).
About this Structure
1CIT is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
DNA-binding mechanism of the monomeric orphan nuclear receptor NGFI-B., Meinke G, Sigler PB, Nat Struct Biol. 1999 May;6(5):471-7. PMID:10331876 Page seeded by OCA on Fri May 2 12:46:36 2008
