1cxl: Difference between revisions

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[[Image:1cxl.gif|left|200px]]
[[Image:1cxl.gif|left|200px]]


{{Structure
<!--
|PDB= 1cxl |SIZE=350|CAPTION= <scene name='initialview01'>1cxl</scene>, resolution 1.810&Aring;
The line below this paragraph, containing "STRUCTURE_1cxl", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G4D:4-DEOXY-ALPHA-D-GLUCOSE'>G4D</scene>, <scene name='pdbligand=GLC:GLUCOSE'>GLC</scene>, <scene name='pdbligand=GLF:1-FLUORO-ALPHA-1-DEOXY-D-GLUCOSE'>GLF</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclomaltodextrin_glucanotransferase Cyclomaltodextrin glucanotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.19 2.4.1.19] </span>
or leave the SCENE parameter empty for the default display.
|GENE=  
-->
|DOMAIN=
{{STRUCTURE_1cxl| PDB=1cxl  | SCENE= }}  
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cxl OCA], [http://www.ebi.ac.uk/pdbsum/1cxl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cxl RCSB]</span>
}}


'''COMPLEX BETWEEN A COVALENT INTERMEDIATE AND BACILLUS CIRCULANS STRAIN 251 CGTASE E257Q'''
'''COMPLEX BETWEEN A COVALENT INTERMEDIATE AND BACILLUS CIRCULANS STRAIN 251 CGTASE E257Q'''
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[[Category: Uitdehaag, J C.M.]]
[[Category: Uitdehaag, J C.M.]]
[[Category: 4- deoxymaltotriose]]
[[Category: 4- deoxymaltotriose]]
[[Category: alpha-amylase family]]
[[Category: Alpha-amylase family]]
[[Category: glycosyl hydrolase family 13]]
[[Category: Glycosyl hydrolase family 13]]
[[Category: intermediate complex]]
[[Category: Intermediate complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:13:13 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:30:34 2008''

Revision as of 10:13, 2 May 2008

File:1cxl.gif

Template:STRUCTURE 1cxl

COMPLEX BETWEEN A COVALENT INTERMEDIATE AND BACILLUS CIRCULANS STRAIN 251 CGTASE E257Q


Overview

Cyclodextrin glycosyltransferase (CGTase) is an enzyme of the alpha-amylase family, which uses a double displacement mechanism to process alpha-linked glucose polymers. We have determined two X-ray structures of CGTase complexes, one with an intact substrate at 2.1 A resolution, and the other with a covalently bound reaction intermediate at 1.8 A resolution. These structures give evidence for substrate distortion and the covalent character of the intermediate and for the first time show, in atomic detail, how catalysis in the alpha-amylase family proceeds by the concerted action of all active site residues.

About this Structure

1CXL is a Single protein structure of sequence from Bacillus circulans. Full crystallographic information is available from OCA.

Reference

X-ray structures along the reaction pathway of cyclodextrin glycosyltransferase elucidate catalysis in the alpha-amylase family., Uitdehaag JC, Mosi R, Kalk KH, van der Veen BA, Dijkhuizen L, Withers SG, Dijkstra BW, Nat Struct Biol. 1999 May;6(5):432-6. PMID:10331869 Page seeded by OCA on Fri May 2 13:13:13 2008

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