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'''CRYSTAL AND MOLECULAR STRUCTURE OF A DNA DUPLEX CONTAINING THE CARCINOGENIC LESION O6-METHYLGUANINE''' | '''CRYSTAL AND MOLECULAR STRUCTURE OF A DNA DUPLEX CONTAINING THE CARCINOGENIC LESION O6-METHYLGUANINE''' | ||
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==About this Structure== | ==About this Structure== | ||
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D24 OCA]. | |||
==Reference== | ==Reference== | ||
Crystal and molecular structure of a DNA duplex containing the carcinogenic lesion O6-methylguanine., Ginell SL, Kuzmich S, Jones RA, Berman HM, Biochemistry. 1990 Nov 20;29(46):10461-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2271657 2271657] | Crystal and molecular structure of a DNA duplex containing the carcinogenic lesion O6-methylguanine., Ginell SL, Kuzmich S, Jones RA, Berman HM, Biochemistry. 1990 Nov 20;29(46):10461-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2271657 2271657] | ||
[[Category: Berman, H M.]] | [[Category: Berman, H M.]] | ||
[[Category: Ginell, S L.]] | [[Category: Ginell, S L.]] | ||
[[Category: Jones, R A.]] | [[Category: Jones, R A.]] | ||
[[Category: Kuzmich, S.]] | [[Category: Kuzmich, S.]] | ||
[[Category: | [[Category: Double helix]] | ||
[[Category: | [[Category: Modified]] | ||
[[Category: | [[Category: Z-dna]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:21:52 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 10:21, 2 May 2008
CRYSTAL AND MOLECULAR STRUCTURE OF A DNA DUPLEX CONTAINING THE CARCINOGENIC LESION O6-METHYLGUANINE
Overview
The crystal and molecular structure of the first DNA duplex containing the carcinogenic lesion O6MeG has been determined to a resolution of 1.9 A and refined to an R factor of 19%. (d[CGC-(O6Me)GCG])2 crystallizes in the left-handed Z DNA form and has crystal parameters and conformational features similar to those of the parent sequence [d(CG)3]2. The methyl groups on O6 of G4 and G10 have C5-C6-O6-O6Me torsion angles of 73 degrees and 56 degrees, respectively, and protrude onto the major groove surface. The base-pairing conformation for the methylated G.C base pairs is of the Watson-Crick type as opposed to a wobble-type conformation that had been proposed in a B DNA fragment. As in other Z DNA structures, a spine of hydration is seen in the minor groove.
About this Structure
Full crystallographic information is available from OCA.
Reference
Crystal and molecular structure of a DNA duplex containing the carcinogenic lesion O6-methylguanine., Ginell SL, Kuzmich S, Jones RA, Berman HM, Biochemistry. 1990 Nov 20;29(46):10461-5. PMID:2271657 Page seeded by OCA on Fri May 2 13:21:52 2008
