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| <scene name='46/465444/Cv/4'>The dimeric E. coli ecotin</scene> with <scene name='46/465444/Cv/3'>thrombin heavy chains and light chains</scene>. | | <scene name='46/465444/Cv/4'>The dimeric E. coli ecotin</scene> with <scene name='46/465444/Cv/3'>thrombin heavy chains and light chains</scene>. |
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| <scene name='46/465444/Cv/6'>Ca+2 ion coordination site</scene> in thrombin heavy chain ([[1id5]]).<ref>PMID:11513582</ref> | | <scene name='46/465444/Cv/6'>Ca+2 ion coordination site</scene> in thrombin heavy chain ([[1id5]]).<ref>PMID:11513582</ref> Water molecules shown as red spheres. |
| </StructureSection> | | </StructureSection> |
| == 3D Structures of Ecotin == | | == 3D Structures of Ecotin == |
Revision as of 13:00, 8 February 2016
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Ecotin (ECO) is a serine protease inhibitor found in the periplasm of E. coli. It is a potent anti and a reversible tight-binding inhibitor of human factor Xa.[1]
The dimeric E. coli ecotin with thrombin heavy chains and light chains.
Ca+2 ion coordination site in thrombin heavy chain (1id5).[2] Water molecules shown as red spheres.
- ↑ Eggers CT, Murray IA, Delmar VA, Day AG, Craik CS. The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase. Biochem J. 2004 Apr 1;379(Pt 1):107-18. PMID:14705961 doi:https://dx.doi.org/10.1042/BJ20031790
- ↑ Wang SX, Esmon CT, Fletterick RJ. Crystal structure of thrombin-ecotin reveals conformational changes and extended interactions. Biochemistry. 2001 Aug 28;40(34):10038-46. PMID:11513582
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3D Structures of Ecotin
Updated on 08-February-2016
{"openlevels":0}
- Ecotin
- Ecotin complex with protein
- 1slu, 1slv, 1slw, 1slx, 1ezs, 1ezu, 4niy – ECO (mutant) + anionic trypsin (mutant)
- 1azz – ECO + collagenase
- 1id5 - ECO (mutant) + thrombin
- 1n8o, 1y6t, 2y6t - ECO + chymotrypsin
- 1p0s - ECO (mutant) + factor Xa
- 1xx9 - ECO (mutant) + factor Xi
- 1xxd, 1xxf - ECO (mutant) + factor Xi (mutant)
- 1fi8 - ECO (mutant) + granzyme B
- 4iw4 – ECO + mannan-binding lectin serine protease
References
