1e0r: Difference between revisions
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'''BETA-APICAL DOMAIN OF THERMOSOME''' | '''BETA-APICAL DOMAIN OF THERMOSOME''' | ||
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[[Category: Bosch, G.]] | [[Category: Bosch, G.]] | ||
[[Category: Essen, L O.]] | [[Category: Essen, L O.]] | ||
[[Category: | [[Category: Chaperonin]] | ||
[[Category: | [[Category: Groel]] | ||
[[Category: | [[Category: Hsp60]] | ||
[[Category: | [[Category: Tcp1]] | ||
[[Category: | [[Category: Thermoplasma acidophilum]] | ||
[[Category: | [[Category: Thermosome]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:30:57 2008'' | |||
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Revision as of 11:30, 2 May 2008
BETA-APICAL DOMAIN OF THERMOSOME
Overview
The crystal structure of the beta-apical domain of the thermosome, an archaeal group II chaperonin from Thermoplasma acidophilum, has been determined at 2.8 A resolution. The structure shows an invariant globular core from which a 25 A long protrusion emanates, composed of an elongated alpha-helix (H10) and a long extended stretch consisting of residues GluB245-ThrB253. A comparison with previous apical domain structures reveals a large segmental displacement of the protruding part of helix H10 via the hinge GluB276-ValB278. The region comprising residues GluB245-ThrB253 adopts an extended beta-like conformation rather than the alpha-helix seen in the alpha-apical domain. Consequently, it appears that the protrusions of the apical domains from group II chaperonins might assume a variety of context-dependent conformations during an open, substrate-accepting state of the chaperonin. Sequence variations in the protrusion regions that are found in the eukaryotic TRiC/CCT subunits may provide different structural propensities and hence serve different roles in substrate recognition.
About this Structure
1E0R is a Single protein structure of sequence from Thermoplasma acidophilum. Full crystallographic information is available from OCA.
Reference
Crystal structure of the beta-apical domain of the thermosome reveals structural plasticity in the protrusion region., Bosch G, Baumeister W, Essen LO, J Mol Biol. 2000 Aug 4;301(1):19-25. PMID:10926489 Page seeded by OCA on Fri May 2 14:30:57 2008
