1f3d: Difference between revisions
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{{STRUCTURE_1f3d| PDB=1f3d | SCENE= }} | |||
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'''CATALYTIC ANTIBODY 4B2 IN COMPLEX WITH ITS AMIDINIUM HAPTEN.''' | '''CATALYTIC ANTIBODY 4B2 IN COMPLEX WITH ITS AMIDINIUM HAPTEN.''' | ||
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==About this Structure== | ==About this Structure== | ||
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F3D OCA]. | |||
==Reference== | ==Reference== | ||
Structural evidence for a programmed general base in the active site of a catalytic antibody., Golinelli-Pimpaneau B, Goncalves O, Dintinger T, Blanchard D, Knossow M, Tellier C, Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):9892-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10963661 10963661] | Structural evidence for a programmed general base in the active site of a catalytic antibody., Golinelli-Pimpaneau B, Goncalves O, Dintinger T, Blanchard D, Knossow M, Tellier C, Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):9892-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10963661 10963661] | ||
[[Category: Blanchard, D.]] | [[Category: Blanchard, D.]] | ||
[[Category: Dintinger, T.]] | [[Category: Dintinger, T.]] | ||
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[[Category: Knossow, M.]] | [[Category: Knossow, M.]] | ||
[[Category: Tellier, C.]] | [[Category: Tellier, C.]] | ||
[[Category: | [[Category: Amidinium]] | ||
[[Category: | [[Category: Catalytic antibody]] | ||
[[Category: | [[Category: Haptenic charge]] | ||
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 12:50, 2 May 2008
CATALYTIC ANTIBODY 4B2 IN COMPLEX WITH ITS AMIDINIUM HAPTEN.
Overview
The crystal structure of the complex of a catalytic antibody with its cationic hapten at 1.9-A resolution demonstrates that the hapten amidinium group is stabilized through an ionic pair interaction with the carboxylate of a combining-site residue. The location of this carboxylate allows it to act as a general base in an allylic rearrangement. When compared with structures of other antibody complexes in which the positive moiety of the hapten is stabilized mostly by cation-pi interactions, this structure shows that the amidinium moiety is a useful candidate to elicit a carboxylate in an antibody combining site at a predetermined location with respect to the hapten. More generally, this structure highlights the advantage of a bidentate hapten for the programmed positioning of a chemically reactive residue in an antibody through charge complementarity to the hapten.
About this Structure
Full crystallographic information is available from OCA.
Reference
Structural evidence for a programmed general base in the active site of a catalytic antibody., Golinelli-Pimpaneau B, Goncalves O, Dintinger T, Blanchard D, Knossow M, Tellier C, Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):9892-5. PMID:10963661 Page seeded by OCA on Fri May 2 15:50:42 2008
