1f59: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:1f59.gif|left|200px]]
[[Image:1f59.gif|left|200px]]


{{Structure
<!--
|PDB= 1f59 |SIZE=350|CAPTION= <scene name='initialview01'>1f59</scene>, resolution 2.8&Aring;
The line below this paragraph, containing "STRUCTURE_1f59", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)
|LIGAND= <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY=  
or leave the SCENE parameter empty for the default display.
|GENE=  
-->
|DOMAIN=
{{STRUCTURE_1f59| PDB=1f59  | SCENE= }}  
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f59 OCA], [http://www.ebi.ac.uk/pdbsum/1f59 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1f59 RCSB]</span>
}}


'''IMPORTIN-BETA-FXFG NUCLEOPORIN COMPLEX'''
'''IMPORTIN-BETA-FXFG NUCLEOPORIN COMPLEX'''
Line 29: Line 26:
[[Category: Littlewood, T.]]
[[Category: Littlewood, T.]]
[[Category: Stewart, M.]]
[[Category: Stewart, M.]]
[[Category: protein-protein complex]]
[[Category: Protein-protein complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 15:55:11 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:16:09 2008''

Revision as of 12:55, 2 May 2008

File:1f59.gif

Template:STRUCTURE 1f59

IMPORTIN-BETA-FXFG NUCLEOPORIN COMPLEX


Overview

We describe the crystal structure of a complex between importin-beta residues 1-442 (Ib442) and five FxFG nucleoporin repeats from Nsp1p. Nucleoporin FxFG cores bind on the convex face of Ib442 to a primary site between the A helices of HEAT repeats 5 and 6, and to a secondary site between HEAT repeats 6 and 7. Mutations at importin-beta Ile178 in the primary FxFG binding site reduce both binding and nuclear protein import, providing direct evidence for the functional significance of the importin-beta-FxFG interaction. The FxFG binding sites on importin-beta do not overlap with the RanGTP binding site. Instead, RanGTP may release importin-beta from FxFG nucleoporins by generating a conformational change that alters the structure of the FxFG binding site.

About this Structure

1F59 is a Single protein structure of sequence from Homo sapiens and Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking., Bayliss R, Littlewood T, Stewart M, Cell. 2000 Jul 7;102(1):99-108. PMID:10929717 Page seeded by OCA on Fri May 2 15:55:11 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1f59&oldid=344426"