5hza: Difference between revisions
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==Crystal structure of GII.10 P domain in complex with 3-fucosyllactose (3 FL)== | |||
<StructureSection load='5hza' size='340' side='right' caption='[[5hza]], [[Resolution|resolution]] 1.35Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5hza]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HZA FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hza OCA], [http://pdbe.org/5hza PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hza RCSB], [http://www.ebi.ac.uk/pdbsum/5hza PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Histo-blood group antigens (HBGAs) are important binding factors for norovirus infections. We show that two human milk oligosaccharides, 2' -fucosyllactose (2' FL) and 3-fucosyllactose (3FL), could block norovirus from binding to surrogate HBGA samples. We found that 2' FL and 3FL bound at the equivalent HBGA pocket on the norovirus capsid using X-ray crystallography. Our data revealed that 2' FL and 3FL structurally mimic HBGAs. These results suggest that 2' FL and 3FL might act as natural-occurring decoys in humans. | |||
Structural Basis for Norovirus Inhibition by Human Milk Oligosaccharides.,Weichert S, Koromyslova A, Singh BK, Hansman S, Jennewein S, Schroten H, Hansman GS J Virol. 2016 Feb 17. pii: JVI.03223-15. PMID:26889023<ref>PMID:26889023</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: Koromyslova, A | <div class="pdbe-citations 5hza" style="background-color:#fffaf0;"></div> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Hansman, G S]] | |||
[[Category: Koromyslova, A D]] | |||
[[Category: Singh, B K]] | |||
[[Category: 3-fucosyllactose]] | |||
[[Category: Hmo]] | |||
[[Category: Human milk]] | |||
[[Category: Norovirus]] | |||
[[Category: P domain]] | |||
[[Category: Viral protein]] | |||
[[Category: Virus]] | |||
Revision as of 14:57, 2 March 2016
Crystal structure of GII.10 P domain in complex with 3-fucosyllactose (3 FL)
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