M2 protein: Difference between revisions
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The '''M2 protein''' (M2) is a proton selective ion | <StructureSection load='4c3e' size='350' side='right' caption='Human α-defensin 1 (PDB entry [[2pm4]])' scene=''> | ||
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== Function == | |||
The '''M2 protein''' (M2) is a proton selective ion channel of the influenza virus<ref>PMID:18045172</ref>. It is activated by low pH. M2 has 3 domains: an ectodomain, transmembrane domain (TM) and a C terminal cytoplasmic domain. See more in:<br /> | |||
[[M2 Proton Channel]]<br /> | [[M2 Proton Channel]]<br /> | ||
[[Molecular Playground/Influenza A M2 transmembrane domain]]<br /> | [[Molecular Playground/Influenza A M2 transmembrane domain]]<br /> | ||
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[[4c3e]] – hrsvM2 (mutant)<br /> | [[4c3e]] – hrsvM2 (mutant)<br /> | ||
[[2l9j]] – hrsvM2 core domain (mutant) - NMR<br /> | [[2l9j]] – hrsvM2 core domain (mutant) - NMR<br /> | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 06:59, 14 April 2016
<StructureSection load='4c3e' size='350' side='right' caption='Human α-defensin 1 (PDB entry 2pm4)' scene=>
Function
The M2 protein (M2) is a proton selective ion channel of the influenza virus[1]. It is activated by low pH. M2 has 3 domains: an ectodomain, transmembrane domain (TM) and a C terminal cytoplasmic domain. See more in:
M2 Proton Channel
Molecular Playground/Influenza A M2 transmembrane domain
M2 Proton Channel Inhibitor Pharmacokinetics.
3D structures of M2 protein
Updated on 14-April-2016
3lbw – IavM2 TM (mutant) – Influenza A virus
3bkd - IavM2 TM
3c9j - IavM2 TM + amantadine
2rlf - IavM2 TM +rimantadine - NMR
2kqt, 1mp6, 1nyj, 2h95 - IavM2 TM – NMR
2kih, 2kwx, 2l0j - IavM2 TM (mutant) – NMR
2ljb, 2ljc - IavM2 TM (mutant)/IbvM2 TM – NMR
2kix - IbvM2 TM (mutant) – Influenza B virus – NMR
2kj1 – IbvM2 cytoplasmic domain - NMR
4c3b, 4c3d – hrsvM2 – Human respiratory syncytial virus
4c3e – hrsvM2 (mutant)
2l9j – hrsvM2 core domain (mutant) - NMR
