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'''CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX''' | '''CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX''' | ||
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[[Category: Weaver, C.]] | [[Category: Weaver, C.]] | ||
[[Category: Xu, W.]] | [[Category: Xu, W.]] | ||
[[Category: | [[Category: Beta-catenin,tcf-3]] | ||
[[Category: | [[Category: Protein-protein complex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:05:31 2008'' | |||
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Revision as of 14:05, 2 May 2008
CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX
Overview
The Wnt signaling pathway plays critical roles in embryonic development and tumorigenesis. Stimulation of the Wnt pathway results in the accumulation of a nuclear beta-catenin/Tcf complex, activating Wnt target genes. A crystal structure of beta-catenin bound to the beta-catenin binding domain of Tcf3 (Tcf3-CBD) has been determined. The Tcf3-CBD forms an elongated structure with three binding modules that runs antiparallel to beta-catenin along the positively charged groove formed by the armadillo repeats. Structure-based mutagenesis defines three sites in beta-catenin that are critical for binding the Tcf3-CBD and are differentially involved in binding APC, cadherin, and Axin. The structural and mutagenesis data reveal a potential target for molecular drug design studies.
About this Structure
1G3J is a Protein complex structure of sequences from Homo sapiens and Xenopus laevis. Full crystallographic information is available from OCA.
Reference
Crystal structure of a beta-catenin/Tcf complex., Graham TA, Weaver C, Mao F, Kimelman D, Xu W, Cell. 2000 Dec 8;103(6):885-96. PMID:11136974 Page seeded by OCA on Fri May 2 17:05:31 2008
