5i2m: Difference between revisions
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==CRYSTAL STRUCTURE OF VSV-INDIANA (MUDD-SUMMERS STRAIN) GLYCOPROTEIN UNDER ITS ACIDIC CONFORMATION== | |||
<StructureSection load='5i2m' size='340' side='right' caption='[[5i2m]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5i2m]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Vesicular_stomatitis_indiana_virus_strain_mudd-summers Vesicular stomatitis indiana virus strain mudd-summers]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2cmz 2cmz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I2M FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i2m OCA], [http://pdbe.org/5i2m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i2m RCSB], [http://www.ebi.ac.uk/pdbsum/5i2m PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The vesicular stomatitis virus has an atypical membrane fusion glycoprotein (G) exhibiting a pH-dependent equilibrium between two forms at the virus surface. Membrane fusion is triggered during the transition from the high- to low-pH form. The structure of G in its low-pH form shows the classic hairpin conformation observed in all other fusion proteins in their postfusion conformation, in spite of a novel fold combining features of fusion proteins from classes I and II. The structure provides a framework for understanding the reversibility of the G conformational change. Unexpectedly, G is homologous to gB of herpesviruses, which raises important questions on viral evolution. | |||
Crystal structure of the low-pH form of the vesicular stomatitis virus glycoprotein G.,Roche S, Bressanelli S, Rey FA, Gaudin Y Science. 2006 Jul 14;313(5784):187-91. PMID:16840692<ref>PMID:16840692</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 5i2m" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Vesicular stomatitis indiana virus strain mudd-summers]] | |||
[[Category: Bressanelli, S]] | [[Category: Bressanelli, S]] | ||
[[Category: Roche, S]] | [[Category: Roche, S]] | ||
[[Category: Envelope protein]] | |||
[[Category: Glycoprotein]] | |||
[[Category: Lipoprotein]] | |||
[[Category: Membrane]] | |||
[[Category: Membrane protein]] | |||
[[Category: Transmembrane]] | |||
