5i3l: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5i3l is ~~ON HOLD~~

==DPF3b in complex with H3K14ac peptide==

~~Authors~~: ~~Tempel~~, W., ~~Liu~~, Y., ~~Walker~~, J.R., ~~Zhao~~, A., ~~Qin~~, S., ~~Loppnau~~, P., ~~Bountra~~, C., Arrowsmith, C.H., Edwards, A.M., ~~Min, J., Structural Genomics Consortium, Structural Genomics Consortium (SGC)~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5i3l]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I3L OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I3L FirstGlance].

~~Description~~: ~~DPF3b in complex with H3K14ac peptide~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i3l OCA], [http://pdbe.org/5i3l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i3l RCSB], [http://www.ebi.ac.uk/pdbsum/5i3l PDBsum]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/DPF3_HUMAN DPF3_HUMAN]] Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development.<ref>PMID:18765789</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Arrowsmith, C H]]

[[Category: Bountra, C]]

[[Category: Edwards, A M]]

[[Category: Liu, Y]]

[[Category: Loppnau, P]]

[[Category: Min, J]]

[[Category: Qin, S]]

[[Category: Structural ~~Genomics Consortium, Structural Genomics Consortium (Sgc)]]~~

[[Category: Structural genomic]]

~~[[Category: Min, J]]~~

~~[[Category: Walker, J.R]]~~

~~[[Category: Liu, Y]]~~

~~[[Category: Bountra, C~~]]

[[Category: Tempel, W]]

[[Category: ~~Loppnau~~, ~~P]]~~

[[Category: Walker, J R]]

~~[[Category: Arrowsmith, C.H~~]]

[[Category: Zhao, A]]

[[Category: ~~Edwards, A.M~~]]

[[Category: Peptide binding protein]]

[[Category: Sgc]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5i3l is ON HOLD
+==DPF3b in complex with H3K14ac peptide==
+<StructureSection load='5i3l' size='340' side='right' caption='[[5i3l]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
-Authors: Tempel, W., Liu, Y., Walker, J.R., Zhao, A., Qin, S., Loppnau, P., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5i3l]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I3L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I3L FirstGlance]. <br>
-Description: DPF3b in complex with H3K14ac peptide
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i3l OCA], [http://pdbe.org/5i3l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i3l RCSB], [http://www.ebi.ac.uk/pdbsum/5i3l PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DPF3_HUMAN DPF3_HUMAN]] Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development.<ref>PMID:18765789</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arrowsmith, C H]]
+[[Category: Bountra, C]]
+[[Category: Edwards, A M]]
+[[Category: Liu, Y]]
+[[Category: Loppnau, P]]
+[[Category: Min, J]]
 [[Category: Qin, S]]
-[[Category: Structural Genomics Consortium, Structural Genomics Consortium (Sgc)]]
+[[Category: Structural genomic]]
-[[Category: Min, J]]
-[[Category: Walker, J.R]]
-[[Category: Liu, Y]]
-[[Category: Bountra, C]]
 [[Category: Tempel, W]]
-[[Category: Loppnau, P]]
+[[Category: Walker, J R]]
-[[Category: Arrowsmith, C.H]]
 [[Category: Zhao, A]]
-[[Category: Edwards, A.M]]
+[[Category: Peptide binding protein]]
+[[Category: Sgc]]