4zkl: Difference between revisions
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==Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) complexed with JB419 (AP4A analog)== | |||
<StructureSection load='4zkl' size='340' side='right' caption='[[4zkl]], [[Resolution|resolution]] 2.34Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4zkl]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZKL FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=JB6:(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[2-[[(2S)-3-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-sulfanyl-phosphoryl]oxy-2-oxidanyl-propoxy]-sulfanyl-phosphoryl]oxyethyl]oxolane-3,4-diol'>JB6</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tw2|3tw2]], [[1kpc|1kpc]]</td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zkl OCA], [http://pdbe.org/4zkl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zkl RCSB], [http://www.ebi.ac.uk/pdbsum/4zkl PDBsum]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/HINT1_HUMAN HINT1_HUMAN]] Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2 (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Baraniak, J]] | |||
[[Category: Dolot, R M]] | |||
[[Category: Kaczmarek, R]] | [[Category: Kaczmarek, R]] | ||
[[Category: Krakowiak, A]] | |||
[[Category: Nawrot, B]] | [[Category: Nawrot, B]] | ||
[[Category: | [[Category: Seda, A]] | ||
[[Category: | [[Category: Ap4a analog]] | ||
[[Category: | [[Category: Complex]] | ||
[[Category: Hint]] | |||
[[Category: Hit]] | |||
[[Category: Hydrolase]] | |||
[[Category: Phosphoramidase]] | |||
Revision as of 15:19, 2 March 2016
Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) complexed with JB419 (AP4A analog)
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