5i69: Difference between revisions
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==MBP-MamC magnetite-interaction component mutant-D70A== | |||
<StructureSection load='5i69' size='340' side='right' caption='[[5i69]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5i69]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I69 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I69 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i69 OCA], [http://pdbe.org/5i69 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i69 RCSB], [http://www.ebi.ac.uk/pdbsum/5i69 PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Magnetotactic bacteria are Gram-negative bacteria that navigate along geomagnetic fields using the magnetosome, an organelle that consists of a membrane-enveloped magnetic nanoparticle. Magnetite formation and its properties are controlled by a specific set of proteins. MamC is a small magnetosome-membrane protein that is known to be active in iron biomineralization but its mechanism has yet to be clarified. Here, we studied the relationship between the MamC magnetite-interaction loop (MIL) structure and its magnetite interaction using an inert biomineralization protein-MamC chimera. Our determined structure shows an alpha-helical fold for MamC-MIL with highly charged surfaces. Additionally, the MamC-MIL induces the formation of larger magnetite crystals compared to protein-free and inert biomineralization protein control experiments. We suggest that the connection between the MamC-MIL structure and the protein's charged surfaces is crucial for magnetite binding and thus for the size control of the magnetite nanoparticles. | |||
Structure-function studies of the magnetite-biomineralizing magnetosome-associated protein MamC.,Nudelman H, Valverde-Tercedor C, Kolusheva S, Perez Gonzalez T, Widdrat M, Grimberg N, Levi H, Nelkenbaum O, Davidov G, Faivre D, Jimenez-Lopez C, Zarivach R J Struct Biol. 2016 Jun;194(3):244-52. doi: 10.1016/j.jsb.2016.03.001. Epub 2016 , Mar 10. PMID:26970040<ref>PMID:26970040</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
[[Category: | <div class="pdbe-citations 5i69" style="background-color:#fffaf0;"></div> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
</StructureSection> | |||
[[Category: Davidove, G]] | |||
[[Category: Faivre, D]] | |||
[[Category: Gonzalez, T P]] | |||
[[Category: Grimberg, N]] | |||
[[Category: Jimenez-Lopez, C]] | [[Category: Jimenez-Lopez, C]] | ||
[[Category: Kolusheva, S]] | [[Category: Kolusheva, S]] | ||
[[Category: Levi, H]] | [[Category: Levi, H]] | ||
[[Category: | [[Category: Nelkenbaum, O]] | ||
[[Category: | [[Category: Nudelman, H]] | ||
[[Category: Tercedor, C V]] | |||
[[Category: Widdrat, M]] | |||
[[Category: Zarivach, R]] | |||
[[Category: Biomineralization]] | |||
[[Category: Magnetite]] | |||
[[Category: Magnetite binding protein]] | |||
[[Category: Magnetotactic bacteria]] | |||
[[Category: Mamc]] | |||
[[Category: Protein-mineral interaction]] | |||
Revision as of 18:02, 10 May 2016
MBP-MamC magnetite-interaction component mutant-D70A
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