Introduction to Evolutionary Conservation: Difference between revisions
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Notice that the conserved residues are scattered around the sequence with no obvious pattern. However, when the same <scene name='Introduction_to_Evolutionary_Conservation/Enolase_with_consurf_colors/1'>colors are applied to the amino acids in the 3D structure</scene>, they form a conserved patch around the catalytic site (marked with a <span style="background:black; color:#00ff00;">''' zinc ion colored green '''</span>. | Notice that the conserved residues are scattered around the sequence with no obvious pattern. However, when the same <scene name='Introduction_to_Evolutionary_Conservation/Enolase_with_consurf_colors/1'>colors are applied to the amino acids in the 3D structure</scene>, they form a conserved patch around the catalytic site (marked with a <span style="background:black; color:#00ff00;">''' zinc ion colored green '''</span>. | ||
*Show [http://firstglance.jmol.org/fg.htm?mol=http%3A//bioinformatics.org/firstglance/fgij/localPDBFiles/4ENLA_ConSurf_DB_pipe.pdb conservation of enolase in FirstGlance in Jmol] ([[4enl]]). | *Show [http://firstglance.jmol.org/fg.htm?mol=http%3A//bioinformatics.org/firstglance/fgij/localPDBFiles/4ENLA_ConSurf_DB_pipe.pdb.gz conservation of enolase in FirstGlance in Jmol] ([[4enl]]). | ||
Conserved surface patches identify functional regions of proteins. Less commonly, patches of high variability may also be functional. (Can you think of situations where high variability would be advantageous?<ref>Advantageous variability will be seen in these cases: [[5hmg]], [[2vaa]], [[3hi6]].</ref>) | Conserved surface patches identify functional regions of proteins. Less commonly, patches of high variability may also be functional. (Can you think of situations where high variability would be advantageous?<ref>Advantageous variability will be seen in these cases: [[5hmg]], [[2vaa]], [[3hi6]].</ref>) | ||
