Matrix metalloproteinase: Difference between revisions
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<StructureSection load='M1.pdb' size='450' side='right' scene='MT1-MMP-TIMP-1_complex/Cv2/8' caption='Complex of MMP14 (magenta) and TIMP-1 (orange) with Ca+2 (green) and Zn+2 (grey) ions (PDB code [[3ma2]])'> | <StructureSection load='M1.pdb' size='450' side='right' scene='MT1-MMP-TIMP-1_complex/Cv2/8' caption='Complex of MMP14 (magenta) and TIMP-1 (orange) with Ca+2 (green) and Zn+2 (grey) ions (PDB code [[3ma2]])'> | ||
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'''Matrix metalloproteinases''' (MMP) are Zinc-dependent endopeptidases. MMP degrades extracellular matrix proteins. MMPs are produced by 28 different genes and are classified according to their protein substrates. They are inhibited by proteases called tissue inhibitors of metalloproteinase (TIMP). The pro-MMP contains a pro-peptide which must be removed to render the MMP active. See details in<br /> | == Function == | ||
'''Matrix metalloproteinases''' (MMP) are Zinc-dependent endopeptidases. MMP degrades extracellular matrix proteins. MMPs are produced by 28 different genes and are classified according to their protein substrates. They are inhibited by proteases called tissue inhibitors of metalloproteinase (TIMP). The pro-MMP contains a pro-peptide which must be removed to render the MMP active<ref>PMID:10419448</ref>. See details in<br /> | |||
* [[Matrix Metalloproteinase 12]]<br /> | * [[Matrix Metalloproteinase 12]]<br /> | ||
* [[Molecular Playground/MMP9]]<br /> | * [[Molecular Playground/MMP9]]<br /> | ||
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* [[Atragin]] for MMP adamalysin<br /> | * [[Atragin]] for MMP adamalysin<br /> | ||
* [[MT1-MMP-TIMP-1 complex]]<br />. | * [[MT1-MMP-TIMP-1 complex]]<br />. | ||
== Relevance == | |||
MMPs have a role in cancer progression<ref>PMID:21087457</ref>. MMP-8, MMP-9, MMP-13 and MMP-14 have a role in periodontal diseases<ref>PMID:8315570</ref>. | |||
{{Clear}} | {{Clear}} | ||
